Invasive Mycoleptodiscus fungal cellulitis and myositis

Sophia Koo; Deanna A. Sutton; Wendy W. Yeh; Elizabeth H. Thompson; Lynne Sigler; Judy F. Shearer; Deborah E. Hofstra; Brian L. Wickes; Francisco M. Marty

doi:10.3109/13693786.2012.656717

Invasive Mycoleptodiscus fungal cellulitis and myositis

Sophia Koo, Deanna A. Sutton, Wendy W. Yeh, Elizabeth H. Thompson, Lynne Sigler, Judy F. Shearer, Deborah E. Hofstra, Brian L. Wickes, Francisco M. Marty

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We report progressive necrotizing fungal cellulitis and myositis in the leg of a patient with glioblastoma multiforme treated with temozolomide and corticosteroids. While the morphologic appearance of the isolate and its ability to grow at temperatures greater than 32°C were suggestive of Mycoleptodiscus indicus, some of the conidia were atypical for this species in that they had single septa and occasional lateral appendages. Furthermore, the isolate was different from M. indicus based on the sequencing analysis of two rDNA regions. This is the first case of Mycoleptodiscus invasive fungal disease in which the causative agent could not be resolved at the species level because of inconsistencies between morphological and molecular data.

Original language	English (US)
Pages (from-to)	740-745
Number of pages	6
Journal	Medical mycology
Volume	50
Issue number	7
DOIs	https://doi.org/10.3109/13693786.2012.656717
State	Published - Oct 2012

Keywords

Dematiaceous
Invasive fungal disease
Mycoleptodiscus
Temozolomide

ASJC Scopus subject areas

Infectious Diseases

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10.3109/13693786.2012.656717

Cite this

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title = "Invasive Mycoleptodiscus fungal cellulitis and myositis",

abstract = "We report progressive necrotizing fungal cellulitis and myositis in the leg of a patient with glioblastoma multiforme treated with temozolomide and corticosteroids. While the morphologic appearance of the isolate and its ability to grow at temperatures greater than 32°C were suggestive of Mycoleptodiscus indicus, some of the conidia were atypical for this species in that they had single septa and occasional lateral appendages. Furthermore, the isolate was different from M. indicus based on the sequencing analysis of two rDNA regions. This is the first case of Mycoleptodiscus invasive fungal disease in which the causative agent could not be resolved at the species level because of inconsistencies between morphological and molecular data.",

keywords = "Dematiaceous, Invasive fungal disease, Mycoleptodiscus, Temozolomide",

author = "Sophia Koo and Sutton, {Deanna A.} and Yeh, {Wendy W.} and Thompson, {Elizabeth H.} and Lynne Sigler and Shearer, {Judy F.} and Hofstra, {Deborah E.} and Wickes, {Brian L.} and Marty, {Francisco M.}",

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language = "English (US)",

volume = "50",

pages = "740--745",

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AU - Koo, Sophia

AU - Sutton, Deanna A.

AU - Yeh, Wendy W.

AU - Thompson, Elizabeth H.

AU - Sigler, Lynne

AU - Shearer, Judy F.

AU - Hofstra, Deborah E.

AU - Wickes, Brian L.

AU - Marty, Francisco M.

PY - 2012/10

Y1 - 2012/10

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AB - We report progressive necrotizing fungal cellulitis and myositis in the leg of a patient with glioblastoma multiforme treated with temozolomide and corticosteroids. While the morphologic appearance of the isolate and its ability to grow at temperatures greater than 32°C were suggestive of Mycoleptodiscus indicus, some of the conidia were atypical for this species in that they had single septa and occasional lateral appendages. Furthermore, the isolate was different from M. indicus based on the sequencing analysis of two rDNA regions. This is the first case of Mycoleptodiscus invasive fungal disease in which the causative agent could not be resolved at the species level because of inconsistencies between morphological and molecular data.

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KW - Invasive fungal disease

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KW - Temozolomide

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Invasive Mycoleptodiscus fungal cellulitis and myositis

Abstract

Keywords

ASJC Scopus subject areas

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