TY - JOUR
T1 - Invariant NKT cells provide innate and adaptive help for B cells
AU - Vomhof-DeKrey, Emilie E.
AU - Yates, Jennifer
AU - Leadbetter, Elizabeth A.
N1 - Funding Information:
Funding was provided by the Trudeau Institute and NIH T32 A1049823 for EEVD.
PY - 2014/6
Y1 - 2014/6
N2 - B cells rely on CD4+ T cells helper signals to optimize their responses to T-dependent antigens. Recently another subset of T cells has been identified which provides help for B cells, invariant natural killer T (iNKT) cells. iNKT cells are unique because they provide both innate and adaptive forms of help to B cells, with divergent outcomes. iNKT cells are widely distributed throughout the spleen at rest, consolidate in the marginal zone of the spleen early after activation, and are later found in germinal centers. Understanding the activation requirements for iNKT cells has led to the development of glycolipid containing nanoparticles which efficiently activate iNKT cells, enhance their cooperation with B cells, and which hold promise for vaccine development.
AB - B cells rely on CD4+ T cells helper signals to optimize their responses to T-dependent antigens. Recently another subset of T cells has been identified which provides help for B cells, invariant natural killer T (iNKT) cells. iNKT cells are unique because they provide both innate and adaptive forms of help to B cells, with divergent outcomes. iNKT cells are widely distributed throughout the spleen at rest, consolidate in the marginal zone of the spleen early after activation, and are later found in germinal centers. Understanding the activation requirements for iNKT cells has led to the development of glycolipid containing nanoparticles which efficiently activate iNKT cells, enhance their cooperation with B cells, and which hold promise for vaccine development.
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U2 - 10.1016/j.coi.2014.01.007
DO - 10.1016/j.coi.2014.01.007
M3 - Review article
C2 - 24514004
AN - SCOPUS:84893565363
SN - 0952-7915
VL - 28
SP - 12
EP - 17
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -