Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner

Irah L. King, Anne Fortier, Michael Tighe, John Dibble, Gerald F.M. Watts, Natacha Veerapen, Ann M. Haberman, Gurdyal S. Besra, Markus Mohrs, Michael B. Brenner, Elizabeth A. Leadbetter

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Abstract

Mouse invariant natural killer T cells (iNKT cells) provide cognate and noncognate help for lipid and protein-specific B cells, respectively. However, the long-term outcome for B cells after cognate help is provided by iNKT cells is unknown at present. Here we found that cognate iNKT cell help resulted in a B cell differentiation program characterized by extrafollicular plasmablasts, germinal-center formation, affinity maturation and a robust primary immunoglobulin G (IgG) antibody response that was uniquely dependent on iNKT cell-derived interleukin 21 (IL-21). However, cognate help from iNKT cells did not generate an enhanced humoral memory response. Thus, cognate iNKT cell help for lipid-specific B cells induces a unique signature that is a hybrid of classic T cell-dependent and T cell-independent type 2 B cell responses.

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalNature Immunology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2012

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

King, I. L., Fortier, A., Tighe, M., Dibble, J., Watts, G. F. M., Veerapen, N., Haberman, A. M., Besra, G. S., Mohrs, M., Brenner, M. B., & Leadbetter, E. A. (2012). Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nature Immunology, 13(1), 44-50. https://doi.org/10.1038/ni.2172