Intrinsic and extrinsic modulation of nitric oxide synthase activity

Linda J. Roman, Pavel Martásek, Bettie Sue Siler Masters

Research output: Contribution to journalArticlepeer-review

172 Scopus citations


The NOS isoforms are modulated by a precise symphony of both intrinsic and extrinsic factors. The overall rate of NO production by each of the isoforms is finely tuned by an amazingly complex combination of intrinsic factors, including the heme environment, and dimerization state, CaM binding, the autoinhibitory domain, and the C-terminal tail region, and extrinsic factors, such as posttranslational modifications, phosphorylation, and specific interactions with other proteins.

Original languageEnglish (US)
Pages (from-to)1179-1189
Number of pages11
JournalChemical Reviews
Issue number4
StatePublished - Apr 2002

ASJC Scopus subject areas

  • Chemistry(all)


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