TY - JOUR
T1 - Intravitreal bevacizumab for treatment of choroidal neovascularization associated with osteogenesis imperfecta
AU - Rishi, Pukhraj
AU - Rishi, Ekta
AU - Venkatraman, Anusha
PY - 2012/5
Y1 - 2012/5
N2 - A 12-year-old girl, diagnosed of osteogenesis imperfecta, presented with sudden visual loss in the left eye. Investigations revealed an active choroidal neovascular membrane. She underwent treatment with intravitreal Bevacizumab (1.25 mg/0.05 ml). Follow-up at 1 month revealed the development of lacquer crack running through the macula, underlying the fovea. The patient received two re-treatments at 1-month intervals, following which the choroidal neovascularization (CNV) regressed completely. However, further progression of lacquer cracks was noted. At the last follow-up, 6 months following the last injection, the fundus remained stable and vision was maintained at 20/200. Considering the natural history of the disease and the increased risk of rupture of the Bruch's membrane in such eyes, the possible complication of a lacquer crack developing must be borne in mind, before initiating treatment.
AB - A 12-year-old girl, diagnosed of osteogenesis imperfecta, presented with sudden visual loss in the left eye. Investigations revealed an active choroidal neovascular membrane. She underwent treatment with intravitreal Bevacizumab (1.25 mg/0.05 ml). Follow-up at 1 month revealed the development of lacquer crack running through the macula, underlying the fovea. The patient received two re-treatments at 1-month intervals, following which the choroidal neovascularization (CNV) regressed completely. However, further progression of lacquer cracks was noted. At the last follow-up, 6 months following the last injection, the fundus remained stable and vision was maintained at 20/200. Considering the natural history of the disease and the increased risk of rupture of the Bruch's membrane in such eyes, the possible complication of a lacquer crack developing must be borne in mind, before initiating treatment.
KW - Bevacizumab
KW - choroidal neovascularization
KW - lacquer crack
KW - osteogenesis imperfecta
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U2 - 10.4103/0301-4738.95882
DO - 10.4103/0301-4738.95882
M3 - Article
C2 - 22569391
AN - SCOPUS:84861325138
SN - 0301-4738
VL - 60
SP - 229
EP - 231
JO - Indian Journal of Ophthalmology
JF - Indian Journal of Ophthalmology
IS - 3
ER -