Intraventricular Flow during Isovolumic Relaxation: Comparison of Normal and Paced Ectopic Excitation under Varied Loading Conditions

Robert W. Price, Joe M. Moody, Bernard J. Rubal, John W. McClure

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In this study, isovolumetric relaxation time (IVRT) flow velocities recorded by pulsed Doppler were induced or augmented in nine patients (aged 60 ± 20 years) with permanent pacemakers. Six subjects had evidence of IVRT flow (≥ 0.2 m/sec) during native rhythm, only three of whom exhibited cavity obliteration. Mean ± SD left ventricular (LV) ejection fraction and end-diastolic and end-systolic volumes were 60% ± 5%, 104 ± 50 mL, and 39 ± 27 mL, respectively. IVRT flows were induced or augmented (P < 0.003) in all patients during paced ectopic stimulation of the right ventricle and during pacing combined with sublingual nitroglycerin (NTG; 0.4 mg). However, IVRT flows were not significantly increased with NTG alone. IVRT flow duration was prolonged > 50% by pacing (P < 0.05). These data suggest that IVRT flows may be present in patients without cavity obliteration and may be accentuated by asynchronous LV relaxation.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
Issue number1
StatePublished - Jan 1 1996


  • Diastole
  • Isovolumetric relaxation
  • Nitroglycerin
  • Pacing

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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