Intraventricular 6-Hydroxydopamine Increases the Adrenal Cortex Mitotic Activity in Rats

A. Lewński; E. Sewerynek; J. Konopacki; M. Pawllkowski; M. K. Lewinska; N. K.R. Smith; R. J. Relter

doi:10.1080/07435808409046765

Intraventricular 6-Hydroxydopamine Increases the Adrenal Cortex Mitotic Activity in Rats

A. Lewński, E. Sewerynek, J. Konopacki, M. Pawllkowski, M. K. Lewinska, N. K.R. Smith, R. J. Relter

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

Abstract

Effects of Intraventricular Injections of 6-hydroxydopamine (6-0HDA) on adrenocortical cell proliferation in rats have been Investigated by means of the colchicine metaphase-arrest technique. in the group of animals receiving 6-OHDA alone, an Increase of mean mitotic activity rate (MMAR) was observed at 96 h and 144 h after Injection. This rise of MMAR was completely inhibited by pretreatment of animals with desmethylimipramine (DMI) - a blocker of norepinephrine uptake. It is concluded that enhancement of ACTH secretion Is responsible for the above mentioned Increase of mitottc activity after 6-OHDA administration. This phenomenon is related to abolition of the Inhibitory noradrenergic effect on ACTH secretion by 6-OHDA treatment. Additionally, the results suggest little or no involvement of dopaminergic neurons in early changes of ACTH secretion after Intraventricular 6-OHDA.

Original language	English (US)
Pages (from-to)	49-61
Number of pages	13
Journal	Endocrine Research
Volume	10
Issue number	1
DOIs	https://doi.org/10.1080/07435808409046765
State	Published - Jan 1984

ASJC Scopus subject areas

Endocrinology

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10.1080/07435808409046765

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@article{ff067c9aac274ae6bd00594ee240b267,

title = "Intraventricular 6-Hydroxydopamine Increases the Adrenal Cortex Mitotic Activity in Rats",

abstract = "Effects of Intraventricular Injections of 6-hydroxydopamine (6-0HDA) on adrenocortical cell proliferation in rats have been Investigated by means of the colchicine metaphase-arrest technique. in the group of animals receiving 6-OHDA alone, an Increase of mean mitotic activity rate (MMAR) was observed at 96 h and 144 h after Injection. This rise of MMAR was completely inhibited by pretreatment of animals with desmethylimipramine (DMI) - a blocker of norepinephrine uptake. It is concluded that enhancement of ACTH secretion Is responsible for the above mentioned Increase of mitottc activity after 6-OHDA administration. This phenomenon is related to abolition of the Inhibitory noradrenergic effect on ACTH secretion by 6-OHDA treatment. Additionally, the results suggest little or no involvement of dopaminergic neurons in early changes of ACTH secretion after Intraventricular 6-OHDA.",

author = "A. Lew{\'n}ski and E. Sewerynek and J. Konopacki and M. Pawllkowski and Lewinska, {M. K.} and Smith, {N. K.R.} and Relter, {R. J.}",

year = "1984",

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doi = "10.1080/07435808409046765",

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T1 - Intraventricular 6-Hydroxydopamine Increases the Adrenal Cortex Mitotic Activity in Rats

AU - Lewński, A.

AU - Sewerynek, E.

AU - Konopacki, J.

AU - Pawllkowski, M.

AU - Lewinska, M. K.

AU - Smith, N. K.R.

AU - Relter, R. J.

PY - 1984/1

Y1 - 1984/1

N2 - Effects of Intraventricular Injections of 6-hydroxydopamine (6-0HDA) on adrenocortical cell proliferation in rats have been Investigated by means of the colchicine metaphase-arrest technique. in the group of animals receiving 6-OHDA alone, an Increase of mean mitotic activity rate (MMAR) was observed at 96 h and 144 h after Injection. This rise of MMAR was completely inhibited by pretreatment of animals with desmethylimipramine (DMI) - a blocker of norepinephrine uptake. It is concluded that enhancement of ACTH secretion Is responsible for the above mentioned Increase of mitottc activity after 6-OHDA administration. This phenomenon is related to abolition of the Inhibitory noradrenergic effect on ACTH secretion by 6-OHDA treatment. Additionally, the results suggest little or no involvement of dopaminergic neurons in early changes of ACTH secretion after Intraventricular 6-OHDA.

AB - Effects of Intraventricular Injections of 6-hydroxydopamine (6-0HDA) on adrenocortical cell proliferation in rats have been Investigated by means of the colchicine metaphase-arrest technique. in the group of animals receiving 6-OHDA alone, an Increase of mean mitotic activity rate (MMAR) was observed at 96 h and 144 h after Injection. This rise of MMAR was completely inhibited by pretreatment of animals with desmethylimipramine (DMI) - a blocker of norepinephrine uptake. It is concluded that enhancement of ACTH secretion Is responsible for the above mentioned Increase of mitottc activity after 6-OHDA administration. This phenomenon is related to abolition of the Inhibitory noradrenergic effect on ACTH secretion by 6-OHDA treatment. Additionally, the results suggest little or no involvement of dopaminergic neurons in early changes of ACTH secretion after Intraventricular 6-OHDA.

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Intraventricular 6-Hydroxydopamine Increases the Adrenal Cortex Mitotic Activity in Rats

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