Intravenous tenecteplase in acute ischemic stroke: An updated review

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Tenecteplase in a genetically engineered variant of alteplase. Although the two have the same mechanism of action, tenecteplase has properties that makes it a seemingly more advantageous thrombolytic. Because of its rapid single-bolus administration, its use is favored over alteplase in the treatment of acute myocardial infarction. Over the past few years, several clinical studies have been conducted to assess the safety, feasibility, and efficacy of tenecteplase in ischemic stroke. In spite of the mixed results of these studies, experimentation with tenecteplase continues in from of clinical trials. In this article, the utility of tenecteplase in ischemic stroke will be discussed.

Original languageEnglish (US)
Pages (from-to)1069-1072
Number of pages4
JournalJournal of Neurology
Volume261
Issue number6
DOIs
StatePublished - Jun 2014
Externally publishedYes

Keywords

  • Alteplase
  • Cerebrovascular disease
  • Pharmacology
  • Stroke
  • Tenecteplase
  • Thrombolysis
  • Thrombolytics
  • Tissue plasminogen activator

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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