Intravenous colchicine for low-back pain: A double-blind study

J. W. Simmons, W. P. Harris, C. W. Koulisis, S. J. Kimmich

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Colchicine, a drug used for centuries in the treatment of gout, has been reported to be effective for low-back pain due to disc disorders. A prospective, randomized, double-blind study evaluating the therapeutic effect of intravenous colchicine was conducted in a group of patients with low-back pain with symptoms originating less an 6 months previously. Each patient completed a questionnaire and a pain drawing. Laboratory studies including uric acid and sedimentation rate were performed, as was a detailed physical examination and lumbar thermography. All treatment parameters (including physical therapy, anti-inflammatory medications, and instructions) were constant except that each patient received either intravenous colchicine or intravenous saline. Results indicate a significant difference between the two groups, the intravenous colchicine group showing improvement in symptoms for a few hours or days over a 3-week course of treatment. However, the relief was often of short duration.

Original languageEnglish (US)
Pages (from-to)716-717
Number of pages2
JournalSpine
Volume15
Issue number7
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Colchicine
Low Back Pain
Double-Blind Method
Gout
Therapeutic Uses
Therapeutics
Uric Acid
Physical Examination
Anti-Inflammatory Agents
Pain
Pharmaceutical Preparations

Keywords

  • intravenous colchicine
  • low-back pain
  • prospective study
  • therapeutic response

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Orthopedics and Sports Medicine

Cite this

Simmons, J. W., Harris, W. P., Koulisis, C. W., & Kimmich, S. J. (1990). Intravenous colchicine for low-back pain: A double-blind study. Spine, 15(7), 716-717. https://doi.org/10.1097/00007632-199007000-00018

Intravenous colchicine for low-back pain : A double-blind study. / Simmons, J. W.; Harris, W. P.; Koulisis, C. W.; Kimmich, S. J.

In: Spine, Vol. 15, No. 7, 1990, p. 716-717.

Research output: Contribution to journalArticle

Simmons, JW, Harris, WP, Koulisis, CW & Kimmich, SJ 1990, 'Intravenous colchicine for low-back pain: A double-blind study', Spine, vol. 15, no. 7, pp. 716-717. https://doi.org/10.1097/00007632-199007000-00018
Simmons, J. W. ; Harris, W. P. ; Koulisis, C. W. ; Kimmich, S. J. / Intravenous colchicine for low-back pain : A double-blind study. In: Spine. 1990 ; Vol. 15, No. 7. pp. 716-717.
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