Intravenous colchicine for low-back pain: A double-blind study

James W. Simmons, William P. Harris, Christo W. Koulisis, Sara J. Kimmich

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Colchicine, a drug used for centuries in the treatment of gout, has been reported to be effective for low-back pain due to disc disorders. A prospective, randomized, double-blind study evaluating the therapeutic effect of intravenous colchicine was conducted in a group of patients with low-back pain with symptoms originating less than 6 months previously. Each patient completed a questionnaire and a pain drawing. Laboratory studies including uric acid and sedimentation rate were per- formed, as was a detailed physical examination and lumbar thermography. All treatment parameters (in- cluding physical therapy, anti-inflammatory medications, and instructions) were constant except that each patient received either intravenous colchicine or intravenous saline. Results indicate a significant difference between the two groups, the intravenous colchicine group show- ing improvement in symptoms for a few hours or days over a 3-week course of treatment. However, the relief was often of short duration.

Original languageEnglish (US)
Pages (from-to)716-717
Number of pages2
JournalSpine
Volume15
Issue number7
DOIs
StatePublished - Jul 1990

Keywords

  • Intravenous colchicine
  • Low-back pain
  • Prospective study
  • Therapeutic response

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology

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