Abstract
We sought to elucidate the mechanisms underlying two common intravascular optical coherence tomography (IV-OCT) artifacts that occur when imaging metallic stents: "merry-go-rounding" (MGR), which is an increase in strut arc length (SAL), and "blooming," which is an increase in the strut reflection thickness (blooming thickness). Due to uncontrollable variables that occur in vivo, we performed an in vitro assessment of MGR and blooming in stented vessel phantoms. Using Xience V and Driver stents, we examined the effects of catheter offset, intimal strut coverage, and residual blood on SAL and blooming thickness in IV-OCT images. Catheter offset and strut coverage both caused minor MGR, while the greatest MGR effect resulted from light scattering by residual blood in the vessel lumen, with 1% hematocrit (Hct) causing a more than fourfold increase in SAL compared with saline (p < 0.001). Residual blood also resulted in blooming, with blooming thickness more than doubling when imaged in 0.5% Hct compared with saline (p < 0.001). We demonstrate that a previously undescribed mechanism, light scattering by residual blood in the imaging field, is the predominant cause of MGR. Light scattering also results in blooming, and a newly described artifact, three-dimensional-MGR, which results in "ghost struts" in B-scans.
| Original language | English (US) |
|---|---|
| Article number | 126017 |
| Journal | Journal of Biomedical Optics |
| Volume | 19 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2014 |
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Keywords
- imaging
- lasers
- stents
- tomography
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
Cite this
Intravascular optical coherence tomography light scattering artifacts : Merry-go-rounding, blooming, and ghost struts. / Mancuso, J. Jacob; Halaney, David L.; Elahi, Sahar; Ho, Derek; Wang, Tianyi; Ouyang, Yongjian; Dijkstra, Jouke; Milner, Thomas E.; Feldman, Marc D.
In: Journal of Biomedical Optics, Vol. 19, No. 12, 126017, 01.12.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intravascular optical coherence tomography light scattering artifacts
T2 - Merry-go-rounding, blooming, and ghost struts
AU - Mancuso, J. Jacob
AU - Halaney, David L.
AU - Elahi, Sahar
AU - Ho, Derek
AU - Wang, Tianyi
AU - Ouyang, Yongjian
AU - Dijkstra, Jouke
AU - Milner, Thomas E.
AU - Feldman, Marc D
PY - 2014/12/1
Y1 - 2014/12/1
N2 - We sought to elucidate the mechanisms underlying two common intravascular optical coherence tomography (IV-OCT) artifacts that occur when imaging metallic stents: "merry-go-rounding" (MGR), which is an increase in strut arc length (SAL), and "blooming," which is an increase in the strut reflection thickness (blooming thickness). Due to uncontrollable variables that occur in vivo, we performed an in vitro assessment of MGR and blooming in stented vessel phantoms. Using Xience V and Driver stents, we examined the effects of catheter offset, intimal strut coverage, and residual blood on SAL and blooming thickness in IV-OCT images. Catheter offset and strut coverage both caused minor MGR, while the greatest MGR effect resulted from light scattering by residual blood in the vessel lumen, with 1% hematocrit (Hct) causing a more than fourfold increase in SAL compared with saline (p < 0.001). Residual blood also resulted in blooming, with blooming thickness more than doubling when imaged in 0.5% Hct compared with saline (p < 0.001). We demonstrate that a previously undescribed mechanism, light scattering by residual blood in the imaging field, is the predominant cause of MGR. Light scattering also results in blooming, and a newly described artifact, three-dimensional-MGR, which results in "ghost struts" in B-scans.
AB - We sought to elucidate the mechanisms underlying two common intravascular optical coherence tomography (IV-OCT) artifacts that occur when imaging metallic stents: "merry-go-rounding" (MGR), which is an increase in strut arc length (SAL), and "blooming," which is an increase in the strut reflection thickness (blooming thickness). Due to uncontrollable variables that occur in vivo, we performed an in vitro assessment of MGR and blooming in stented vessel phantoms. Using Xience V and Driver stents, we examined the effects of catheter offset, intimal strut coverage, and residual blood on SAL and blooming thickness in IV-OCT images. Catheter offset and strut coverage both caused minor MGR, while the greatest MGR effect resulted from light scattering by residual blood in the vessel lumen, with 1% hematocrit (Hct) causing a more than fourfold increase in SAL compared with saline (p < 0.001). Residual blood also resulted in blooming, with blooming thickness more than doubling when imaged in 0.5% Hct compared with saline (p < 0.001). We demonstrate that a previously undescribed mechanism, light scattering by residual blood in the imaging field, is the predominant cause of MGR. Light scattering also results in blooming, and a newly described artifact, three-dimensional-MGR, which results in "ghost struts" in B-scans.
KW - imaging
KW - lasers
KW - stents
KW - tomography
UR - http://www.scopus.com/inward/record.url?scp=84922576098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922576098&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.19.12.126017
DO - 10.1117/1.JBO.19.12.126017
M3 - Article
C2 - 25545341
AN - SCOPUS:84922576098
VL - 19
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 12
M1 - 126017
ER -