Intraosseous infusion of hypertonic glucose and dopamine

Steven Neish, M. G. Macon, J. W M Moore, G. M. Graeber

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Intraosseous infusion of drugs for resuscitation and of fluids has been advocated as an alternate emergency technique to intravenous infusion. The reliability of intraosseous infusion of many substances has not been established. Glucose and dopamine hydrochloride are two commonly used emergency drugs in pediatric practice that have not been carefully studied when administered into the bone marrow. In an animal model, we compared the response of an intraosseous injection of hypertonic glucose with that of an intravenous injection of hypertonic glucose. Serum glucose measurements following the injection revealed both routes of administration to be effective. A dopamine infusion was then administered through the bone marrow for 20 minutes. A statistically significant rise in blood pressure was observed two minutes after initiation of the infusion. Intraosseous infusion of hypertonic glucose and dopamine is an effective route by which to administer these medications and is potentially useful in emergency situations in which intravascular access is delayed.

Original languageEnglish (US)
Pages (from-to)878-800
Number of pages79
JournalAmerican Journal of Diseases of Children
Volume142
Issue number8
StatePublished - 1988
Externally publishedYes

Fingerprint

Intraosseous Infusions
Dopamine
Glucose
Emergencies
Bone Marrow
Injections
Intravenous Infusions
Resuscitation
Intravenous Injections
Pharmaceutical Preparations
Animal Models
Pediatrics
Blood Pressure
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Neish, S., Macon, M. G., Moore, J. W. M., & Graeber, G. M. (1988). Intraosseous infusion of hypertonic glucose and dopamine. American Journal of Diseases of Children, 142(8), 878-800.

Intraosseous infusion of hypertonic glucose and dopamine. / Neish, Steven; Macon, M. G.; Moore, J. W M; Graeber, G. M.

In: American Journal of Diseases of Children, Vol. 142, No. 8, 1988, p. 878-800.

Research output: Contribution to journalArticle

Neish, S, Macon, MG, Moore, JWM & Graeber, GM 1988, 'Intraosseous infusion of hypertonic glucose and dopamine', American Journal of Diseases of Children, vol. 142, no. 8, pp. 878-800.
Neish, Steven ; Macon, M. G. ; Moore, J. W M ; Graeber, G. M. / Intraosseous infusion of hypertonic glucose and dopamine. In: American Journal of Diseases of Children. 1988 ; Vol. 142, No. 8. pp. 878-800.
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