Intraoperative radiation therapy (IORT) to the tumor bed only for breast cancer: Technique and outcome

Gary M. Proulx, Thelma C Hurd, R. Jeffrey Lee, Paul C. Stomper, Matthew B. Podgorsak, Stephen B. Edge

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background. Recent published reports have demonstrated that not all patients with early stage breast cancer need the entire breast irradiated for local control of their disease. To address the difficulties of several weeks of irradiation treatment, investigators have utilized different radiation techniques and treatment schedules that reduce the overall treatment time without compromising outcome. Patients and methods. An analysis was made of 7 patients treated on protocol with local intraoperative radiation (IORT) alone to the lumpectomy site after surgery with or without axillary dissection. All patients received IORT with 120 kV x-rays to the tumor bed at the time of resection. Doses ranged from 1500 cGy to 2000 cGy. Three patients were stage I, two stage IIA, and two stage IIB. Results. With a mean follow up of 123 months (range 86 to 139 months), two of seven patients developed a local recurrence which were treated with mastectomy. The disease specific survival is 100% and overall survival is 86% with one patient being dead without disease. The cosmetic outcome of the 5 patients with their treated breast remaining have expressed satisfaction with the results. No treatment related complications have occurred. Conclusions. The results o four pilot study support the findings that not all patients with early stage breast cancer need the entire breast irradiated for durable local control of their disease. However, patient numbers in this study are low and any conclusions need further evaluation with larger trials.

Original languageEnglish (US)
JournalRadiology and Oncology
Volume35
Issue number1
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Radiotherapy
Breast Neoplasms
Neoplasms
Breast
Radiation
Survival
Segmental Mastectomy
Mastectomy
Therapeutics
Cosmetics
Dissection
Appointments and Schedules
Research Personnel
X-Rays
Recurrence

Keywords

  • Breast cancer
  • Breast conservation therapy
  • Breast neoplasms-radiotherapy
  • Intraoperative radiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Proulx, G. M., Hurd, T. C., Lee, R. J., Stomper, P. C., Podgorsak, M. B., & Edge, S. B. (2001). Intraoperative radiation therapy (IORT) to the tumor bed only for breast cancer: Technique and outcome. Radiology and Oncology, 35(1).

Intraoperative radiation therapy (IORT) to the tumor bed only for breast cancer : Technique and outcome. / Proulx, Gary M.; Hurd, Thelma C; Lee, R. Jeffrey; Stomper, Paul C.; Podgorsak, Matthew B.; Edge, Stephen B.

In: Radiology and Oncology, Vol. 35, No. 1, 01.01.2001.

Research output: Contribution to journalArticle

Proulx, Gary M. ; Hurd, Thelma C ; Lee, R. Jeffrey ; Stomper, Paul C. ; Podgorsak, Matthew B. ; Edge, Stephen B. / Intraoperative radiation therapy (IORT) to the tumor bed only for breast cancer : Technique and outcome. In: Radiology and Oncology. 2001 ; Vol. 35, No. 1.
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