Intragastric satiety-inducing device reduces food intake and suppresses body weight gain in a rodent model

Yingen Luo, Xiaowu Zhang, Jiaywei Tsauo, Hwoon Yong Jung, Ho Young Song, He Zhao, Jingui Li, Tao Gong, Peng Song, Xiao Li

Research output: Contribution to journalArticlepeer-review

Abstract

Background: An intragastric satiety-inducing device (ISD) (Full Sense Device; Baker, Foote, Kemmeter, Walburn, LLC, Grand Rapids, MI) is a novel weight-loss device, which may induce satiety by applying continuous pressure on the gastric cardia. This study investigated the effect of the ISD on food intake and body weight gain in a rodent model. Methods: Thirty-two male Sprague–Dawley rats (weight, 250–300 g) were randomly divided into four groups of eight individuals. Single-disk (SD) and double-disk (DD) group animals underwent peroral placement of a single- or double-disk ISD, respectively, under fluoroscopic guidance. The ISD comprised a 4 mm × 1.5 cm nitinol stent placed in the lower esophagus and one (single-disk) or two (double-disk) 2.5-cm-diameter star-shaped nitinol disks placed in the gastric fundus. Esophageal stent (ES) and sham-operated (SO) group animals underwent peroral placement of the ES part of the ISD and a sham operation, respectively. Results: Food intake was significantly different among the four groups over the 4-week study period (P < 0.001); food intake was significantly lower in the SD and DD groups than in the SO group (P = 0.016 and P = 0.002, respectively) but was not significantly different between the SD and DD groups (P > 0.999) and between the ES and SO groups (P = 0.677). Body weight was significantly different among the four groups by the end of the study period (P < 0.001); body weight was significantly lower in the DD group than in the SD, ES, and SO groups (P = 0.010, P < 0.001, and P < 0.001, respectively) and in the SD group than in the SO group (P = 0.001), but it was not significantly different between the ES and SO groups (P = 0.344). Conclusion: ISD reduced food intake and suppressed body weight gain in a rodent model.

Original languageEnglish (US)
Pages (from-to)1052-1057
Number of pages6
JournalSurgical endoscopy
Volume35
Issue number3
DOIs
StatePublished - Mar 2021
Externally publishedYes

Keywords

  • Bariatric medicine
  • Bariatrics
  • Obesity
  • Obesity management
  • Self-expandable metallic stents
  • Weight loss

ASJC Scopus subject areas

  • Surgery

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