Intradiscal steroids:A prospective double-blind clinical trial

J. W. Simmons, J. N. McMillin, S. F. Emery, S. J. Kimmich

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


A prospective, randomized, doubla-bllnd study was performed to evaluate the clinical efficacy of intradiscal steroid Injections, Criteria (or entrance were one-level internal disc disruption or nonsequasterad nuclear prolapse wish or without sciatica and a positive pain response on awake discography. Exclusion criteria were multilevel disease, central or lateral stenosis, prior lumbar surgery, or medical disease requiring systemic steroids. A total 35 patients were randomly assfgnod to Treatment Group A (methyiprodnisolono, Depo- Medrol BO mg/ml, The Upjohn Co., Kalamazoo, Michigan) or Treatment Group B (bupivacalne, Marcaine. 5% 1.5 ml, Sanofi Winthrop Pharmaceuticals, New Yorfc, New YorJO, Fourteen pallents received Dopa-Modrol, with 21% showing subjective improvement and 79% no improvement; 0% warn clinically worse. Eleven patients received intradiscal Marcaine, with 9% showing clinical improvement and 91% no Improvement; 0% were clinically worse. To quantify clinical response, a pain diagram grid score, a visual analog scale, and the Oswestry Pain Questionnaire were used before injection and 10-14 days after Injection. No statistically significant bauefit was identified in the use of intradiscal steroids.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
Issue number6
StatePublished - Jun 1992


  • Intradiscal steroid injection

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology


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