Intracellular Regulation of Ion Channels in Cell Membranes

DEBORAH L. LEWIS; JAMES D. LECHLEITER; DONGHEE KIM; CHAYA NANAVATI; DAVID E. CLAPHAM

doi:10.1016/S0025-6196(12)62726-8

Intracellular Regulation of Ion Channels in Cell Membranes

DEBORAH L. LEWIS
, JAMES D. LECHLEITER
, DONGHEE KIM
, CHAYA NANAVATI
, DAVID E. CLAPHAM

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Cells communicate with their environment through receptor proteins on the cell membrane. Some ion channels are receptors, whereas others are linked to receptors through guanine nucleotide-binding proteins (G proteins). Ion channels control intracellular concentrations of ions such as calcium, and these concentrations control cell functions such as secretion and cell division. This review summarizes the current state of knowledge about the control of ion channels.

Original language	English (US)
Pages (from-to)	1127-1143
Number of pages	17
Journal	Mayo Clinic Proceedings
Volume	65
Issue number	8
DOIs	https://doi.org/10.1016/S0025-6196(12)62726-8
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0025-6196(12)62726-8

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@article{5d98622fe646468f916fef11f61cc290,

title = "Intracellular Regulation of Ion Channels in Cell Membranes",

abstract = "Cells communicate with their environment through receptor proteins on the cell membrane. Some ion channels are receptors, whereas others are linked to receptors through guanine nucleotide-binding proteins (G proteins). Ion channels control intracellular concentrations of ions such as calcium, and these concentrations control cell functions such as secretion and cell division. This review summarizes the current state of knowledge about the control of ion channels.",

author = "LEWIS, \{DEBORAH L.\} and LECHLEITER, \{JAMES D.\} and DONGHEE KIM and CHAYA NANAVATI and CLAPHAM, \{DAVID E.\}",

note = "Funding Information: This work was supported in part by Grants HL 34873 and HL 41303 from the National Institutes of Health, Public Health Service. ",

year = "1990",

doi = "10.1016/S0025-6196(12)62726-8",

language = "English (US)",

volume = "65",

pages = "1127--1143",

journal = "Mayo Clinic Proceedings",

issn = "0025-6196",

publisher = "Elsevier Ltd",

number = "8",

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TY - JOUR

T1 - Intracellular Regulation of Ion Channels in Cell Membranes

AU - LEWIS, DEBORAH L.

AU - LECHLEITER, JAMES D.

AU - KIM, DONGHEE

AU - NANAVATI, CHAYA

AU - CLAPHAM, DAVID E.

N1 - Funding Information: This work was supported in part by Grants HL 34873 and HL 41303 from the National Institutes of Health, Public Health Service.

PY - 1990

Y1 - 1990

N2 - Cells communicate with their environment through receptor proteins on the cell membrane. Some ion channels are receptors, whereas others are linked to receptors through guanine nucleotide-binding proteins (G proteins). Ion channels control intracellular concentrations of ions such as calcium, and these concentrations control cell functions such as secretion and cell division. This review summarizes the current state of knowledge about the control of ion channels.

AB - Cells communicate with their environment through receptor proteins on the cell membrane. Some ion channels are receptors, whereas others are linked to receptors through guanine nucleotide-binding proteins (G proteins). Ion channels control intracellular concentrations of ions such as calcium, and these concentrations control cell functions such as secretion and cell division. This review summarizes the current state of knowledge about the control of ion channels.

UR - https://www.scopus.com/pages/publications/0024986239

UR - https://www.scopus.com/pages/publications/0024986239#tab=citedBy

U2 - 10.1016/S0025-6196(12)62726-8

DO - 10.1016/S0025-6196(12)62726-8

M3 - Review article

C2 - 1697015

AN - SCOPUS:0024986239

SN - 0025-6196

VL - 65

SP - 1127

EP - 1143

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

IS - 8

ER -

Intracellular Regulation of Ion Channels in Cell Membranes

Abstract

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