Intracellular Regulation of Ion Channels in Cell Membranes

DEBORAH L. LEWIS, JAMES D. LECHLEITER, DONGHEE KIM, CHAYA NANAVATI, DAVID E. CLAPHAM

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Cells communicate with their environment through receptor proteins on the cell membrane. Some ion channels are receptors, whereas others are linked to receptors through guanine nucleotide-binding proteins (G proteins). Ion channels control intracellular concentrations of ions such as calcium, and these concentrations control cell functions such as secretion and cell division. This review summarizes the current state of knowledge about the control of ion channels.

Original languageEnglish (US)
Pages (from-to)1127-1143
Number of pages17
JournalMayo Clinic Proceedings
Volume65
Issue number8
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Medicine(all)

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