Intracellular proteolysis: signals of selective protein degradation

N. N. Starkova, E. P. Koroleva, T. V. Rotanova

Research output: Contribution to journalArticle

Abstract

Selective proteolysis is one of the mechanisms for the maintenance of cell homeostasis via rapid degradation of defective polypeptides and certain short-lived regulatory proteins. In prokaryotic cells, highmolecular-mass oligomeric ATP-dependent proteases are responsible for selective protein degradation. In eukaryotes, most polypeptides are attacked by the multicatalytic 26S proteasome, and the degradation of the majority of substrates involves their preliminary modification with the protein ubiquitin. The proteins undergoing the selective proteolysis often contain specific degradation signals necessary for their recognition by the corresponding proteases.

Original languageEnglish (US)
Pages (from-to)71-84
Number of pages14
JournalRussian Journal of Bioorganic Chemistry
Volume26
Issue number2
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • ATP-dependent proteases
  • Degradation signals
  • Pmteasome
  • Selective proteolysis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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