Intracellular concentration of potassium and other elements in vaginal epithelial cells stimulated by estradiol administration

Ivan L. Cameron, Thomas B. Pool, Nancy K.R. Smith

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Electron probe x‐ray microanalysis was used to measure cytoplasmic elemental content (in mmoles/kg dry weight) of the basal layer of cells of the vaginal epithelium of ovariectomized rats. Measurements were made both before estradiol injection and at 2 hr, 17 hr, and 24 hr after estradiol administration. Mitotic figures first appeared in the basal cell layer at 24 hr. During the course of the study significant time‐dependent differences were seen in the content of all elements measured. A pattern of change in cytoplasmic content was seen for Na, P, S, and Cl; all of which decrease significantly by 17 hr and then return to approximately the nonstimulated concentration by 24 hr. On the other hand K, and to a lesser extent Mg, show an early and continued increase in cytoplasmic content after estradiol injection. Thus, the marked increase in the intracytoplasmic content of K in the estradiol treated cells suggests that K, or the ratio of Na to K, may be directly or indirectly involved in growth stimulation.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalJournal of Cellular Physiology
Volume104
Issue number1
DOIs
StatePublished - Jul 1980
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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