TY - JOUR
T1 - Intraamniotic deamino(D-Arg8)-vasopressin
T2 - Prolonged effects on ovine fetal urine flow and swallowing
AU - Kullama, L. K.
AU - Nijland, M. J.M.
AU - Ervin, M. G.
AU - Ross, M. G.
PY - 1996
Y1 - 1996
N2 - OBJECTIVE: Fetal urine is the main source of amniotic fluid, and alterations in urine production have an impact on amniotic fluid dynamics. Intraamniotic arginine vasopressin is absorbed into fetal plasma, but fetal antidiuretic responses may be obscured by vasoconstrictor (V1 receptor) actions of arginine vasopressin. We determined the effects of intraamniotic administration of a specific V2 receptor agonist, deamino(D-Arg8)- vasopressin, on fetal plasma arginine vasopressin immunoreactivity, fetal urine output, and swallowing. STUDY DESIGN: Six chronically prepared pregnant ewes (129 ± 1 days' gestation) received a single deamino(D-Arg8) (50 μg injection into the amniotic fluid with subsequent measurement of fetal plasma arginine vasopressin immunoreactivity, fetal urine flow and osmolality, and fetal swallowing. RESULTS: Within 30 minutes of deamino(D-Arg8)-vasopressin administration, fetal plasma arginine vasopressin immunoreactivity (4.5 ± 0.5 to 76.4 ± 21.9 pg/ml) and urine osmolality (135 ± 13 to 285 ± 43 mOsm/kg H2O) significantly increased and urine flow decreased (0.18 ± 0.01 to 0.05 ± 0.01 ml/kg per minute). After 48 hours urine flow remained reduced (0.08 ± 0.03 ml/kg per minute) and osmolality remained elevated (399 ± 18 mOsm/kg H2O). There were no changes in fetal swallowing, systolic (64 ± 3 mm Hg) or diastolic (42 ± 3 mm Hg) blood pressure, or heart rate (169 ± 6 beats/min). CONCLUSION: Intraamniotic deamino(D-Arg8)-vasopressin administration evokes persistent fetal antidiuresis in the absence of arginine vasopressin-induced fetal cardiovascular effects or changes in fetal swallowed volume, indicating its suitability as a potential therapeutic agent in amniotic fluid volume disorders such as polyhydramnios.
AB - OBJECTIVE: Fetal urine is the main source of amniotic fluid, and alterations in urine production have an impact on amniotic fluid dynamics. Intraamniotic arginine vasopressin is absorbed into fetal plasma, but fetal antidiuretic responses may be obscured by vasoconstrictor (V1 receptor) actions of arginine vasopressin. We determined the effects of intraamniotic administration of a specific V2 receptor agonist, deamino(D-Arg8)- vasopressin, on fetal plasma arginine vasopressin immunoreactivity, fetal urine output, and swallowing. STUDY DESIGN: Six chronically prepared pregnant ewes (129 ± 1 days' gestation) received a single deamino(D-Arg8) (50 μg injection into the amniotic fluid with subsequent measurement of fetal plasma arginine vasopressin immunoreactivity, fetal urine flow and osmolality, and fetal swallowing. RESULTS: Within 30 minutes of deamino(D-Arg8)-vasopressin administration, fetal plasma arginine vasopressin immunoreactivity (4.5 ± 0.5 to 76.4 ± 21.9 pg/ml) and urine osmolality (135 ± 13 to 285 ± 43 mOsm/kg H2O) significantly increased and urine flow decreased (0.18 ± 0.01 to 0.05 ± 0.01 ml/kg per minute). After 48 hours urine flow remained reduced (0.08 ± 0.03 ml/kg per minute) and osmolality remained elevated (399 ± 18 mOsm/kg H2O). There were no changes in fetal swallowing, systolic (64 ± 3 mm Hg) or diastolic (42 ± 3 mm Hg) blood pressure, or heart rate (169 ± 6 beats/min). CONCLUSION: Intraamniotic deamino(D-Arg8)-vasopressin administration evokes persistent fetal antidiuresis in the absence of arginine vasopressin-induced fetal cardiovascular effects or changes in fetal swallowed volume, indicating its suitability as a potential therapeutic agent in amniotic fluid volume disorders such as polyhydramnios.
KW - Amniotic fluid volume
KW - arginine vasopressin
KW - deamino(D- Arg)-vasopressin
KW - fetal urine
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U2 - 10.1016/S0002-9378(96)70377-0
DO - 10.1016/S0002-9378(96)70377-0
M3 - Article
C2 - 8572038
AN - SCOPUS:0030040237
VL - 174
SP - 78
EP - 84
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 1
ER -