Intestinal Metabolism in Thiamine Deficiency

G. I. Henderson, D. W. McCandless, S. Schenker

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Severe thiamine deficiency in rats was found to depress intestinal mucosal pyruvate decarboxylase and transketolase activities by 56 and 93% (p < 0.05), respectively. Whole gut transketolase activity in thiamine deficiency was also reduced by 70-80% (p < 0.05). Despite the major decline in intestinal pyruvate decarboxylase activity, ATP levels in both mucosa and whole gut of thiamine-deficient rats remained normal. By contrast, the decrease in mucosal transketo-lase activity in thiamine-deficient animals was accompanied by a 40% decline in pentose cycle activity (p < 0.05), which reverted to normal after administration of thiamine.

Original languageEnglish (US)
Pages (from-to)596-602
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume144
Issue number2
DOIs
StatePublished - Nov 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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