TY - JOUR
T1 - Intestinal Metabolism in Thiamine Deficiency
AU - Henderson, G. I.
AU - McCandless, D. W.
AU - Schenker, S.
N1 - Funding Information:
This research was supported by a grant from the National Institutes of Health, No. 5RO1 MH-19200-03, and V. A. Research funds.
PY - 1973/11
Y1 - 1973/11
N2 - Severe thiamine deficiency in rats was found to depress intestinal mucosal pyruvate decarboxylase and transketolase activities by 56 and 93% (p < 0.05), respectively. Whole gut transketolase activity in thiamine deficiency was also reduced by 70-80% (p < 0.05). Despite the major decline in intestinal pyruvate decarboxylase activity, ATP levels in both mucosa and whole gut of thiamine-deficient rats remained normal. By contrast, the decrease in mucosal transketo-lase activity in thiamine-deficient animals was accompanied by a 40% decline in pentose cycle activity (p < 0.05), which reverted to normal after administration of thiamine.
AB - Severe thiamine deficiency in rats was found to depress intestinal mucosal pyruvate decarboxylase and transketolase activities by 56 and 93% (p < 0.05), respectively. Whole gut transketolase activity in thiamine deficiency was also reduced by 70-80% (p < 0.05). Despite the major decline in intestinal pyruvate decarboxylase activity, ATP levels in both mucosa and whole gut of thiamine-deficient rats remained normal. By contrast, the decrease in mucosal transketo-lase activity in thiamine-deficient animals was accompanied by a 40% decline in pentose cycle activity (p < 0.05), which reverted to normal after administration of thiamine.
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U2 - 10.3181/00379727-144-37642
DO - 10.3181/00379727-144-37642
M3 - Article
C2 - 4746932
AN - SCOPUS:0015887335
VL - 144
SP - 596
EP - 602
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
SN - 1535-3702
IS - 2
ER -