Intestinal Dysbiosis and Tryptophan Metabolism in Autoimmunity

Josephine Brown, Brian Robusto, Laurence Morel

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

The development of autoimmunity involves complex interactions between genetics and environmental triggers. The gut microbiota is an important environmental constituent that can heavily influence both local and systemic immune reactivity through distinct mechanisms. It is therefore a relevant environmental trigger or amplifier to consider in autoimmunity. This review will examine recent evidence for an association between intestinal dysbiosis and autoimmune diseases, and the mechanisms by which the gut microbiota may contribute to autoimmune activation. We will specifically focus on recent studies connecting tryptophan metabolism to autoimmune disease pathogenesis and discuss evidence for a microbial origin. This will be discussed in the context of our current understanding of how tryptophan metabolites regulate immune responses, and how it may, or may not, be applicable to autoimmunity.

Original languageEnglish (US)
Pages (from-to)1741
Number of pages1
JournalFrontiers in immunology
Volume11
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • autoimmunity
  • dysbiosis
  • kynurenine
  • metabolites
  • microbiota
  • tryptophan

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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