Interval approach to assessing antitumor activity for tumor xenograft studies

Jianrong Wu, Peter J. Houghton

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In preclinical cancer drug screening tumor xenograft experiments, the tumor growth inhibition ratio (T/C) is commonly used to assess the antitumor activity of the agents. Unfortunately, this measurement can discard useful data and result in a high false-negative rate. Furthermore, the degree of antitumor activity based on the T/C ratio is assessed on the basis of an arbitrary cutoff point that does not reflect variations in different tumor lines. To overcome these drawbacks, we propose an adjusted area-under-the-curve (aAUC) ratio to quantify tumor growth inhibition. A nonparametric bootstrap t-interval of the aAUC ratio is also proposed for assessing the significance of the antitumor activity of the agents. The proposed method is then applied to a real tumor xenograft study.

Original languageEnglish (US)
Pages (from-to)46-54
Number of pages9
JournalPharmaceutical Statistics
Volume9
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Antitumor activity
  • Area under the curve
  • Bootstrap
  • Confidence interval
  • Xenografts

ASJC Scopus subject areas

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)

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