Intersubtype human immunodeficiency virus type 1 superinfection following seroconversion to primary infection in two injection drug users

Artur Ramos, Dale J. Hu, Lily Nguyen, Kim Oanh Phan, Suphak Vanichseni, Nattawan Promadej, Kachit Choopanya, Margaret Callahan, Nancy L. Young, Janet McNicholl, Timothy D. Mastro, Thomas M. Folks, Shambavi Subbarao

    Research output: Contribution to journalArticle

    149 Scopus citations

    Abstract

    In this study, we describe two cases of human immunodeficiency virus type 1 (HIV-1) intersubtype super-infection with CRF01-AE and subtype B strains, which occurred in two injection drug users participating in a prospective cohort study in Bangkok, Thailand. In both cases, the superinfecting strain was detected by molecular and serologic analyses several weeks after complete seroconversion to the primary infection with a strain belonging to a different subtype. Superinfection occurred despite specific T-cell and humoral antibody responses to the primary virus. In both cases, cross-subtype immune responses were limited or absent prior to the second infection. These data show that, in some individuals, the quality and quantity of the immune response elicited by primary HIV-1 infection may not protect against superinfection. This finding has important implications for vaccine design. HIV-1 vaccines, at a minimum, will need to include potent, broadly protective, conserved immunogens derived from several group M subtypes.

    Original languageEnglish (US)
    Pages (from-to)7444-7452
    Number of pages9
    JournalJournal of virology
    Volume76
    Issue number15
    DOIs
    StatePublished - Jul 23 2002

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

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  • Cite this

    Ramos, A., Hu, D. J., Nguyen, L., Phan, K. O., Vanichseni, S., Promadej, N., Choopanya, K., Callahan, M., Young, N. L., McNicholl, J., Mastro, T. D., Folks, T. M., & Subbarao, S. (2002). Intersubtype human immunodeficiency virus type 1 superinfection following seroconversion to primary infection in two injection drug users. Journal of virology, 76(15), 7444-7452. https://doi.org/10.1128/JVI.76.15.7444-7452.2002