Intersubtype human immunodeficiency virus type 1 superinfection following seroconversion to primary infection in two injection drug users

Artur Ramos, Dale J. Hu, Lily Nguyen, Kim Oanh Phan, Suphak Vanichseni, Nattawan Promadej, Kachit Choopanya, Margaret Callahan, Nancy L. Young, Janet McNicholl, Timothy D. Mastro, Thomas M. Folks, Shambavi Subbarao

Research output: Contribution to journalArticlepeer-review

151 Scopus citations

Abstract

In this study, we describe two cases of human immunodeficiency virus type 1 (HIV-1) intersubtype super-infection with CRF01-AE and subtype B strains, which occurred in two injection drug users participating in a prospective cohort study in Bangkok, Thailand. In both cases, the superinfecting strain was detected by molecular and serologic analyses several weeks after complete seroconversion to the primary infection with a strain belonging to a different subtype. Superinfection occurred despite specific T-cell and humoral antibody responses to the primary virus. In both cases, cross-subtype immune responses were limited or absent prior to the second infection. These data show that, in some individuals, the quality and quantity of the immune response elicited by primary HIV-1 infection may not protect against superinfection. This finding has important implications for vaccine design. HIV-1 vaccines, at a minimum, will need to include potent, broadly protective, conserved immunogens derived from several group M subtypes.

Original languageEnglish (US)
Pages (from-to)7444-7452
Number of pages9
JournalJournal of virology
Volume76
Issue number15
DOIs
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Fingerprint

Dive into the research topics of 'Intersubtype human immunodeficiency virus type 1 superinfection following seroconversion to primary infection in two injection drug users'. Together they form a unique fingerprint.

Cite this