Abstract
A 76-year-old male with a history of renal insufficiency was found to have anemia, an IgM kappa paraprotein on serum immunofixation studies, absence of lytic bone lesions, and findings in the bone marrow consistent with Waldenström macroglobulinemia (WM). Cytogenetic studies including fluorescence in situ hybridization (FISH) on the post-treatment bone marrow revealed the karyotype 46,XY,del(20)(q13.1q13.3). Less than 70 cases of karyotypic abnormalities in patients with WM have been reported, which have shown no abnormalities specific to WM. Monosomy or trisomy of chromosome 20 has been reported in approximately eight cases, but to our knowledge this is the first case report of an interstitial deletion of 20q, confirmed by FISH using chromosome 20 subtelomeric specific probes. Interstitial deletions of 20q are known to occur in polycythemia vera and other hematological malignancies, especially those of myeloid origin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 145-148 |
| Number of pages | 4 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 132 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 15 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
Cite this
Interstitial deletion of 20q in a patient with Waldenström macroglobulinemia following chemotherapy. / Blann, Melissa M.; Velagaleti, Gopalrao V; Morgan, David L.; Martinez, Rodolfo E.; Conlin, Phillip A.; Tonk, Vijay S.
In: Cancer Genetics and Cytogenetics, Vol. 132, No. 2, 15.01.2002, p. 145-148.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interstitial deletion of 20q in a patient with Waldenström macroglobulinemia following chemotherapy
AU - Blann, Melissa M.
AU - Velagaleti, Gopalrao V
AU - Morgan, David L.
AU - Martinez, Rodolfo E.
AU - Conlin, Phillip A.
AU - Tonk, Vijay S.
PY - 2002/1/15
Y1 - 2002/1/15
N2 - A 76-year-old male with a history of renal insufficiency was found to have anemia, an IgM kappa paraprotein on serum immunofixation studies, absence of lytic bone lesions, and findings in the bone marrow consistent with Waldenström macroglobulinemia (WM). Cytogenetic studies including fluorescence in situ hybridization (FISH) on the post-treatment bone marrow revealed the karyotype 46,XY,del(20)(q13.1q13.3). Less than 70 cases of karyotypic abnormalities in patients with WM have been reported, which have shown no abnormalities specific to WM. Monosomy or trisomy of chromosome 20 has been reported in approximately eight cases, but to our knowledge this is the first case report of an interstitial deletion of 20q, confirmed by FISH using chromosome 20 subtelomeric specific probes. Interstitial deletions of 20q are known to occur in polycythemia vera and other hematological malignancies, especially those of myeloid origin.
AB - A 76-year-old male with a history of renal insufficiency was found to have anemia, an IgM kappa paraprotein on serum immunofixation studies, absence of lytic bone lesions, and findings in the bone marrow consistent with Waldenström macroglobulinemia (WM). Cytogenetic studies including fluorescence in situ hybridization (FISH) on the post-treatment bone marrow revealed the karyotype 46,XY,del(20)(q13.1q13.3). Less than 70 cases of karyotypic abnormalities in patients with WM have been reported, which have shown no abnormalities specific to WM. Monosomy or trisomy of chromosome 20 has been reported in approximately eight cases, but to our knowledge this is the first case report of an interstitial deletion of 20q, confirmed by FISH using chromosome 20 subtelomeric specific probes. Interstitial deletions of 20q are known to occur in polycythemia vera and other hematological malignancies, especially those of myeloid origin.
UR - http://www.scopus.com/inward/record.url?scp=0037081749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037081749&partnerID=8YFLogxK
U2 - 10.1016/S0165-4608(01)00538-6
DO - 10.1016/S0165-4608(01)00538-6
M3 - Article
C2 - 11850077
AN - SCOPUS:0037081749
VL - 132
SP - 145
EP - 148
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -