Interstitial deletion of 20q in a patient with Waldenström macroglobulinemia following chemotherapy

Melissa M. Blann, Gopalrao V.N. Velagaleti, David L. Morgan, Rodolfo E. Martinez, Phillip A. Conlin, Vijay S. Tonk

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A 76-year-old male with a history of renal insufficiency was found to have anemia, an IgM kappa paraprotein on serum immunofixation studies, absence of lytic bone lesions, and findings in the bone marrow consistent with Waldenström macroglobulinemia (WM). Cytogenetic studies including fluorescence in situ hybridization (FISH) on the post-treatment bone marrow revealed the karyotype 46,XY,del(20)(q13.1q13.3). Less than 70 cases of karyotypic abnormalities in patients with WM have been reported, which have shown no abnormalities specific to WM. Monosomy or trisomy of chromosome 20 has been reported in approximately eight cases, but to our knowledge this is the first case report of an interstitial deletion of 20q, confirmed by FISH using chromosome 20 subtelomeric specific probes. Interstitial deletions of 20q are known to occur in polycythemia vera and other hematological malignancies, especially those of myeloid origin.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalCancer Genetics and Cytogenetics
Issue number2
StatePublished - Jan 15 2002
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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