Interstitial deletion of 20q in a patient with Waldenström macroglobulinemia following chemotherapy

Melissa M. Blann, Gopalrao V Velagaleti, David L. Morgan, Rodolfo E. Martinez, Phillip A. Conlin, Vijay S. Tonk

Research output: Contribution to journalArticle

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Abstract

A 76-year-old male with a history of renal insufficiency was found to have anemia, an IgM kappa paraprotein on serum immunofixation studies, absence of lytic bone lesions, and findings in the bone marrow consistent with Waldenström macroglobulinemia (WM). Cytogenetic studies including fluorescence in situ hybridization (FISH) on the post-treatment bone marrow revealed the karyotype 46,XY,del(20)(q13.1q13.3). Less than 70 cases of karyotypic abnormalities in patients with WM have been reported, which have shown no abnormalities specific to WM. Monosomy or trisomy of chromosome 20 has been reported in approximately eight cases, but to our knowledge this is the first case report of an interstitial deletion of 20q, confirmed by FISH using chromosome 20 subtelomeric specific probes. Interstitial deletions of 20q are known to occur in polycythemia vera and other hematological malignancies, especially those of myeloid origin.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume132
Issue number2
DOIs
StatePublished - Jan 15 2002
Externally publishedYes

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Waldenstrom Macroglobulinemia
Fluorescence In Situ Hybridization
Drug Therapy
Bone Marrow
Chromosomes, Human, Pair 20
Paraproteins
Monosomy
Polycythemia Vera
Hematologic Neoplasms
Karyotype
Cytogenetics
Renal Insufficiency
Immunoglobulin M
Anemia
Bone and Bones
Serum
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Interstitial deletion of 20q in a patient with Waldenström macroglobulinemia following chemotherapy. / Blann, Melissa M.; Velagaleti, Gopalrao V; Morgan, David L.; Martinez, Rodolfo E.; Conlin, Phillip A.; Tonk, Vijay S.

In: Cancer Genetics and Cytogenetics, Vol. 132, No. 2, 15.01.2002, p. 145-148.

Research output: Contribution to journalArticle

Blann, Melissa M. ; Velagaleti, Gopalrao V ; Morgan, David L. ; Martinez, Rodolfo E. ; Conlin, Phillip A. ; Tonk, Vijay S. / Interstitial deletion of 20q in a patient with Waldenström macroglobulinemia following chemotherapy. In: Cancer Genetics and Cytogenetics. 2002 ; Vol. 132, No. 2. pp. 145-148.
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