Interplay between neuroimmunoendocrine systems during post-traumatic stress disorder: A minireview

Moisés E. Bauer; Andréa Wieck; Rodrigo P. Lopes; Antonio L. Teixeira; Rodrigo Grassi-Oliveira

doi:10.1159/000258721

Interplay between neuroimmunoendocrine systems during post-traumatic stress disorder: A minireview

Moisés E. Bauer, Andréa Wieck, Rodrigo P. Lopes, Antonio L. Teixeira, Rodrigo Grassi-Oliveira

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Early life stress has been suggested to mediate vulnerability to affective disorders. Traumatic events experienced in childhood such as sexual abuse and/or physical neglect may lead to psychiatric diseases in adult life, including post-traumatic stress disorder (PTSD). Previous studies have focused on adult traumatic events and very little is known regarding the long-term physiological effects of early life stress. Here, we review the complex interplay between most important cognitive, neuroendocrine and immunological changes reported in PTSD, focusing on long-term implications of childhood maltreatment. PTSD has been associated with significant biological changes related to impaired cognitive functions, attenuated hypothalamic-pituitary-adrenal (HPA) axis function (hypocortisolism) and activation of innate immune responses (low-grade inflammation).

Original language	English (US)
Pages (from-to)	192-195
Number of pages	4
Journal	NeuroImmunoModulation
Volume	17
Issue number	3
DOIs	https://doi.org/10.1159/000258721
State	Published - Feb 2010
Externally published	Yes

Keywords

Cortisol
Cytokines
Hypocortisolism
Inflammation
Lymphocytes
Post-traumatic stress disorder

ASJC Scopus subject areas

Immunology
Endocrinology
Neurology
Endocrine and Autonomic Systems

Access to Document

10.1159/000258721

Cite this

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abstract = "Early life stress has been suggested to mediate vulnerability to affective disorders. Traumatic events experienced in childhood such as sexual abuse and/or physical neglect may lead to psychiatric diseases in adult life, including post-traumatic stress disorder (PTSD). Previous studies have focused on adult traumatic events and very little is known regarding the long-term physiological effects of early life stress. Here, we review the complex interplay between most important cognitive, neuroendocrine and immunological changes reported in PTSD, focusing on long-term implications of childhood maltreatment. PTSD has been associated with significant biological changes related to impaired cognitive functions, attenuated hypothalamic-pituitary-adrenal (HPA) axis function (hypocortisolism) and activation of innate immune responses (low-grade inflammation).",

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AU - Teixeira, Antonio L.

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Interplay between neuroimmunoendocrine systems during post-traumatic stress disorder: A minireview

Abstract

Keywords

ASJC Scopus subject areas

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