Interplay between neuroimmunoendocrine systems during post-traumatic stress disorder: A minireview

Moisés E. Bauer, Andréa Wieck, Rodrigo P. Lopes, Antonio L. Teixeira, Rodrigo Grassi-Oliveira

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Early life stress has been suggested to mediate vulnerability to affective disorders. Traumatic events experienced in childhood such as sexual abuse and/or physical neglect may lead to psychiatric diseases in adult life, including post-traumatic stress disorder (PTSD). Previous studies have focused on adult traumatic events and very little is known regarding the long-term physiological effects of early life stress. Here, we review the complex interplay between most important cognitive, neuroendocrine and immunological changes reported in PTSD, focusing on long-term implications of childhood maltreatment. PTSD has been associated with significant biological changes related to impaired cognitive functions, attenuated hypothalamic-pituitary-adrenal (HPA) axis function (hypocortisolism) and activation of innate immune responses (low-grade inflammation).

Original languageEnglish (US)
Pages (from-to)192-195
Number of pages4
Issue number3
StatePublished - Feb 2010
Externally publishedYes


  • Cortisol
  • Cytokines
  • Hypocortisolism
  • Inflammation
  • Lymphocytes
  • Post-traumatic stress disorder

ASJC Scopus subject areas

  • Immunology
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems


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