Interplay between mycoplasmas and host target cells

J. B. Baseman, M. Lange, N. L. Criscimagna, J. A. Giron, C. A. Thomas

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


The infectious pattern of mycoplasmas (Mycoplasma penetrans, Mycoplasma pneumoniaeandMycoplasma genitalium) in mammalian cells was examined using confocal microscopy and flow cytometry combined with cell fractionation and mycoplasma viability determinations. Within 2 h postinfection mycoplasmas parasitize cell surfaces, enter the intracellular spaces and locate throughout the cytoplasmic and perinuclear regions. These mycoplasmas can be cultivated from cytoplasmic and nuclear fractions 96 h later and continue to persist intracellularly for at least 7 days, suggesting a much more active intracellular role for mycoplasmas than had been considered previously.

Original languageEnglish (US)
Pages (from-to)105-116
Number of pages12
JournalMicrobial Pathogenesis
Issue number2
StatePublished - Aug 1995


  • Adherence
  • Confocal microscopy
  • Flow cytometry
  • Invasion
  • Mammalian cells
  • Mycoplasmas

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases


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