International study of mechanical ventilation: Effect of age

Antonio Anzueto, A. Esteban, I. Alia, F. Gordo, W. Ely, J. Melo, M. J. Tobin

Research output: Contribution to journalArticlepeer-review


Purpose: To determine the effect of age in mechanically ventilated patients from different countries. Methods: Prevalence Study. A questionnaire was completed on all patients on mechanical ventilation on the day and time of the study. Each study parameter was specifically defined for the investigators. Results: 412 ICUs in eight countries were involved in the study. On the day of study, 1638 of the 4153 ICU patients were receiving mechanical ventilation. Patients were divided arbitrary in two group: < 75 years and > 75 years. <75 yr. >75 yr. p N 1355 254 Days ICU 21 ± 107 15 ± 23 0.06 Days - MV 21 ± 110 14 ± 23 0.02 Apache II 19 ± 8 22 ± 8 <0.001 CPE 87 (10%) 46 (24%) <0.001 AECOPD 171(13%) 40(16%) NS Mean ±SD. ARF= Acute Respiratory Failure. CPE: Cardiogenic Pulmonary edema. AECOPD: Acute exacerbation of chronic obstructive pulmonary disease. No geographic differences were noted for age, modes of mechanical ventilation or weaning techniques. Conclusions: Patients over 75 years of age had a significantly shorter time on mechanical ventilation with an associated worse Apache II score. Cardiogenic pulmonary edema was the more common cause for respiratory failure. Clinical Implications: Age > 75 is not a factor that determines the need of mechanical ventilation. The impact of age on overall morbidity and mortality of mechanical ventilation needs to be addressed in a prospective study.

Original languageEnglish (US)
Pages (from-to)357S
Issue number4 SUPPL.
StatePublished - Oct 1 1998

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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