Interleukin-6 and verbal memory in recurrent major depressive disorder

Rodrigo Grassi-Oliveira, Moisés Evandro Bauer, Júlio Carlos Pezzi, Antonio Lucio Teixeira, Elisa Brietzke

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


OBJECTIVE: To evaluate the possible association between peripheral levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) with immediate and delayed verbal recall in a group of recurrent depressed women. METHODS: Logical Memory Subtests of the Wechsler Memory Scale - Revised was administered to 30 patients with recurrent major depressive disorder with no clinical and psychiatric comorbidities. Blood samples were collected from 8:00 am to 9:00 am, before memory assessments. Plasma was stored and ELISA assay was used to detect IL-6 and TNF-alpha levels. RESULTS: There was a statistically significant association between IL-6 levels and immediate verbal recall (IVR) (B=-0.787, p=0.000) and delayed verbal recall (DVR) (B=-0.695, p=0.001) even after controlling for age, depression severity and body mass index. CONCLUSION: The results of this study indicated that low performances in IVR and DVR are associated with higher IL-6 levels in women with recurrent MDD. The results of this study suggest the existence of an association between inflammatory imbalance and cognitive impairment in MDD.

Original languageEnglish (US)
Pages (from-to)540-544
Number of pages5
JournalNeuroendocrinology Letters
Issue number4
StatePublished - 2011
Externally publishedYes


  • Cognition
  • Cytokines
  • Inflammation
  • Memory
  • Mood disorders

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health


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