@article{8e02d4f6b6af472bbeabb36503b6e7b0,
title = "Interleukin-12 enhances clinical experimental autoimmune myasthenia gravis in susceptible but not resistant mice",
abstract = "Experimental autoimmune myasthenia gravis (EAMG) is induced by antibodies against the nicotinic acetylcholine receptor (AChR). Studies indicate a role for interferon-γ (IFN-γ) in EAMG. We examined the effect of IL-12, a major inducer of IFN-γ production, on EAMG in C57BL/6 mice. Five doses of IL-12 accelerated and enhanced clinical disease in AChR-immunized mice. Control B6 mice, IFN-γ gene-knockout mice, and EAMG-resistant bm12 mice showed no enhancement of disease. Shifting to a Th1-type antibody isotype distribution was insufficient to cause disease. Other factors, such as direct effects of Th1 cytokines on muscle tissue, may be involved in EAMG susceptibility. Copyright (C) 2000 Elsevier Science B.V.",
keywords = "Autoantibodies, Cytokines, Experimental autoimmune myasthenia gravis",
author = "Sheela Sitaraman and Metzger, {Dennis W.} and Belloto, {Robert J.} and Infante, {Anthony J.} and Wall, {Katherine A.}",
note = "Funding Information: We thank Dr. Sheila Grimes and the Animal Disease Diagnostic Laboratory of the Ohio Department of Agriculture for production of histology slides, Dr. Christine Ng-Bautista for assistance in microscopy and photography, Dr. James Auberle for assistance in interpretation of the slides, and Dr. George A. Milliken of the Department of Statistics, Kansas Sate University for his suggestions on statistical analysis. Genetics Institute generously supplied the IL-12 that made the work possible. We thank Dr. Channing Hinman for advice on acetylcholine receptor preparation, Sunghan Yim for anti-AChR assays, and Ms. Mariola Klis for expert technical assistance. This work was supported by a grant from the deArce Memorial Endowment Fund (K.A.W.) and by National Institutes of Health Grants AI41715 (D.W.M.) and NS29093 (A.J.I., K.A.W.).",
year = "2000",
month = jul,
day = "10",
doi = "10.1016/S0165-5728(00)00259-9",
language = "English (US)",
volume = "107",
pages = "73--82",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1",
}