Interferon Induction by Rhinoviruses and Effect of Interferon on Rhinovirus Yields in Human Cell Lines

D. Stoker, J. Kiernat, C. Gauntt

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Rhinovirus serotypes 13, 14, and 20 did not induce detectable levels of interferon in HeLa, KB, or L-132 cells following challenge with infectious, uv-in-activated, or heat-inactivated virus preparations. HeLa cell cultures incubated with interferon prior to challenge with the three rhinovirus serotypes also failed to produce interferon. No resistance to VSV plaque formation was induced in HeLa cell cultures previously challenged with uv- or heat-inactivated lysates of the three rhinovirus serotypes. Replication of the three rhinovirus serotypes in HeLa cell cultures was inhibited by the action of interferon with an order of sensitivity being RV13 < RV14 < RV20.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume143
Issue number1
DOIs
StatePublished - May 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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