Interferon-γ Modulates Melatonin Production in Rat Pineal Glands in Organ Culture

Boonsirm Withyachumnarnkul, Keico O. Nonaka, Celsa Santana, Ahmed M. Attia, Russel J. Reiter

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

The effect of interferon-γ (IFN-γ) on melatonin production was determined in rat pineal glands in organ culture. IFN-γ enhanced the production of melatonin in the glands incubated with either 10 nM or 1,000 nM isoproterenol (ISO, a β-adrenergic receptor agonist) but decreased the l00nM ISO response. The enhanced melatonin production was accompanied by either unchanged or a lower level of N-acetyltransferase (NAT) activity, whereas the suppression was accompanied by a reduced NAT activity. IFN-γ did not change the activity of the enzyme hydroxyindole-O-methyltransferase (HIOMT) in the ISO-stimulated pineal glands. The results indicate that IFN-γ has a dual action on the pineal gland: One is to increase melatonin production through yet unknown mechanisms, and the other is to suppress NAT activity. These results also suggest that the pineal gland, under physiological stimulation, is modulated by IFN-γ to increase melatonin production. A hypothetical model is proposed to explain the delicate regulation of pineal function by the immune system.

Original languageEnglish (US)
Pages (from-to)403-411
Number of pages9
JournalJournal of Interferon Research
Volume10
Issue number4
DOIs
StatePublished - Aug 1990

ASJC Scopus subject areas

  • Immunology
  • Virology

Fingerprint Dive into the research topics of 'Interferon-γ Modulates Melatonin Production in Rat Pineal Glands in Organ Culture'. Together they form a unique fingerprint.

Cite this