Interactions of the pineal gland, blinding, and underfeeding on reproductive organ size and radioimmunoassayable growth hormone

Sandy Sorrentino, Russel J. Reiter, Don S. Schalch

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Restricting male rats to one-half normal food intake from day 25 until day 60 of life significantly delayed all aspects of normal growth that were measured. Body weights were reduced by 50% and pituitary growth hormone (GH) and plasma GH levels were scvcrly reduced compared with corresponding values of ad libitum controls. Underfeeding also partially inhibited testicular and accessory organ growth. If underfeeding was combined with blinding, a more marked inhibition of testicular and accessory organ growth occurred. The effect of combining blinding and underfeeding was more dramatic than the effect of each treatment independently, indicating an accentuation of the response with the combination of treat- ments. This marked lag in development of the reproductive organs of blinded underfed rats was apparently mediated by the pineal gland, since blinded-pinealectomized underfed rats had reproductive organs that were considerably larger than those of blinded underfed rats.

Original languageEnglish (US)
Pages (from-to)105-115
Number of pages11
JournalNeuroendocrinology
Volume7
Issue number2
DOIs
StatePublished - 1971
Externally publishedYes

Keywords

  • Blinding
  • Body growth
  • Endocrine glands
  • Growth hormone
  • Pineal gland
  • Underfeeding

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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