Interactions of plant lectins with glycolipids in liposomes

David H. Boldt, Stephen F. Speckart, Roberta L. Richards, Carl R. Alving

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

A panel of five plant lectins with different binding specificities was used to determine if plant lectins could bind specifically to membrane-associated glycolipids. Ricinis communis and wheat germ agglutinins both bound specifically to mixed brain gangliosides and globoside I from human erythrocytes. Wheat germ agglutinin also bound to ganglioside GM1 and human erythrocyte ceramide trihexoside, but not to ceramide dihexoside, mono-, or digalactosyl diglycerides. Concanavalin A bound to liposomes with or without glycolipid substituents, and this binding was partially inhibited by α-methyl mannoside. This study indicates that lectins can specifically recognize and bind to certain glycolipids in membranes.

Original languageEnglish (US)
Pages (from-to)208-214
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume74
Issue number1
DOIs
StatePublished - Jan 10 1977
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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