Interactions of γ-hydroxy butyrate with ethanol and NCS 382

Richard J. Lamb, Jaclyn Munn, Nicklaus J. Duiker, Andrew Coop, Huifang Wu, Wouter Koek, Charles P. France

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We examined the effects of γ-hydroxy butyrate (GHB) alone and in combination with either ethanol or NCS 382 [(2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene], a purported antagonist at the GHB receptor. These effects were examined on the responding of rats under a fixed-ratio (FR) 10 schedule of sugar solution (14%, w/v; 0.1 ml) presentation. GHB dose-relatedly decreased responding. When GHB was combined with ethanol, the effects of the two drugs were less than additive. NCS 382 did not antagonize the rate-decreasing effects of GHB. These observations are consistent with the notion that many of the behavioral actions of exogenously administered GHB result from GHB's actions at sites other than the GHB receptor, and are inconsistent with the popular notion that the effects of GHB and ethanol are synergistic.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalEuropean Journal of Pharmacology
Volume470
Issue number3
DOIs
StatePublished - Jun 6 2003

Keywords

  • (Rat)
  • Drug interaction
  • Ethanol
  • GHB (γ-hydroxy butyrate)
  • NCS 382
  • Schedule-controlled behavior

ASJC Scopus subject areas

  • Pharmacology

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