Interactions of γ-hydroxy butyrate with ethanol and NCS 382

Richard J. Lamb; Jaclyn Munn; Nicklaus J. Duiker; Andrew Coop; Huifang Wu; Wouter Koek; Charles P. France

doi:10.1016/S0014-2999(03)01791-6

Interactions of γ-hydroxy butyrate with ethanol and NCS 382

Richard J. Lamb, Jaclyn Munn, Nicklaus J. Duiker, Andrew Coop, Huifang Wu, Wouter Koek, Charles P. France

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We examined the effects of γ-hydroxy butyrate (GHB) alone and in combination with either ethanol or NCS 382 [(2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene], a purported antagonist at the GHB receptor. These effects were examined on the responding of rats under a fixed-ratio (FR) 10 schedule of sugar solution (14%, w/v; 0.1 ml) presentation. GHB dose-relatedly decreased responding. When GHB was combined with ethanol, the effects of the two drugs were less than additive. NCS 382 did not antagonize the rate-decreasing effects of GHB. These observations are consistent with the notion that many of the behavioral actions of exogenously administered GHB result from GHB's actions at sites other than the GHB receptor, and are inconsistent with the popular notion that the effects of GHB and ethanol are synergistic.

Original language	English (US)
Pages (from-to)	157-162
Number of pages	6
Journal	European Journal of Pharmacology
Volume	470
Issue number	3
DOIs	https://doi.org/10.1016/S0014-2999(03)01791-6
State	Published - Jun 6 2003

Keywords

(Rat)
Drug interaction
Ethanol
GHB (γ-hydroxy butyrate)
NCS 382
Schedule-controlled behavior

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/S0014-2999(03)01791-6

Cite this

@article{533f0f7415c442178cc1110e7be20102,

title = "Interactions of γ-hydroxy butyrate with ethanol and NCS 382",

abstract = "We examined the effects of γ-hydroxy butyrate (GHB) alone and in combination with either ethanol or NCS 382 [(2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene], a purported antagonist at the GHB receptor. These effects were examined on the responding of rats under a fixed-ratio (FR) 10 schedule of sugar solution (14%, w/v; 0.1 ml) presentation. GHB dose-relatedly decreased responding. When GHB was combined with ethanol, the effects of the two drugs were less than additive. NCS 382 did not antagonize the rate-decreasing effects of GHB. These observations are consistent with the notion that many of the behavioral actions of exogenously administered GHB result from GHB's actions at sites other than the GHB receptor, and are inconsistent with the popular notion that the effects of GHB and ethanol are synergistic.",

keywords = "(Rat), Drug interaction, Ethanol, GHB (γ-hydroxy butyrate), NCS 382, Schedule-controlled behavior",

author = "Lamb, {Richard J.} and Jaclyn Munn and Duiker, {Nicklaus J.} and Andrew Coop and Huifang Wu and Wouter Koek and France, {Charles P.}",

note = "Funding Information: We would like to acknowledge the technical assistance of Carlos Velez. All procedures were approved by the Institutional Animal Care and Use Committee of The University of Texas Health Sciences Center at San Antonio. Preliminary results of this investigation were presented at the annual CPDD meeting, Quebec City, Quebec, June 2002. Supported in part by NIH grants AA 12337 and DA 14986. CPF was supported by Research Scientist Development Award DA 00211. JM and ND were supported by summer fellowships from the American Society for Pharmacology and Experimental Therapeutics.",

year = "2003",

month = jun,

day = "6",

doi = "10.1016/S0014-2999(03)01791-6",

language = "English (US)",

volume = "470",

pages = "157--162",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Interactions of γ-hydroxy butyrate with ethanol and NCS 382

AU - Lamb, Richard J.

AU - Munn, Jaclyn

AU - Duiker, Nicklaus J.

AU - Coop, Andrew

AU - Wu, Huifang

AU - Koek, Wouter

AU - France, Charles P.

N1 - Funding Information: We would like to acknowledge the technical assistance of Carlos Velez. All procedures were approved by the Institutional Animal Care and Use Committee of The University of Texas Health Sciences Center at San Antonio. Preliminary results of this investigation were presented at the annual CPDD meeting, Quebec City, Quebec, June 2002. Supported in part by NIH grants AA 12337 and DA 14986. CPF was supported by Research Scientist Development Award DA 00211. JM and ND were supported by summer fellowships from the American Society for Pharmacology and Experimental Therapeutics.

PY - 2003/6/6

Y1 - 2003/6/6

N2 - We examined the effects of γ-hydroxy butyrate (GHB) alone and in combination with either ethanol or NCS 382 [(2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene], a purported antagonist at the GHB receptor. These effects were examined on the responding of rats under a fixed-ratio (FR) 10 schedule of sugar solution (14%, w/v; 0.1 ml) presentation. GHB dose-relatedly decreased responding. When GHB was combined with ethanol, the effects of the two drugs were less than additive. NCS 382 did not antagonize the rate-decreasing effects of GHB. These observations are consistent with the notion that many of the behavioral actions of exogenously administered GHB result from GHB's actions at sites other than the GHB receptor, and are inconsistent with the popular notion that the effects of GHB and ethanol are synergistic.

AB - We examined the effects of γ-hydroxy butyrate (GHB) alone and in combination with either ethanol or NCS 382 [(2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene], a purported antagonist at the GHB receptor. These effects were examined on the responding of rats under a fixed-ratio (FR) 10 schedule of sugar solution (14%, w/v; 0.1 ml) presentation. GHB dose-relatedly decreased responding. When GHB was combined with ethanol, the effects of the two drugs were less than additive. NCS 382 did not antagonize the rate-decreasing effects of GHB. These observations are consistent with the notion that many of the behavioral actions of exogenously administered GHB result from GHB's actions at sites other than the GHB receptor, and are inconsistent with the popular notion that the effects of GHB and ethanol are synergistic.

KW - (Rat)

KW - Drug interaction

KW - Ethanol

KW - GHB (γ-hydroxy butyrate)

KW - NCS 382

KW - Schedule-controlled behavior

UR - http://www.scopus.com/inward/record.url?scp=0037868959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037868959&partnerID=8YFLogxK

U2 - 10.1016/S0014-2999(03)01791-6

DO - 10.1016/S0014-2999(03)01791-6

M3 - Article

C2 - 12798953

AN - SCOPUS:0037868959

SN - 0014-2999

VL - 470

SP - 157

EP - 162

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

Interactions of γ-hydroxy butyrate with ethanol and NCS 382

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this