TY - JOUR
T1 - Interactions between alcohol metabolism genes and religious involvement in association with maximum drinks and alcohol dependence symptoms
AU - Chartier, Karen G.
AU - Dick, Danielle M.
AU - Almasy, Laura
AU - Chan, Grace
AU - Aliev, Fazil
AU - Schuckit, Marc A.
AU - Scott, Denise M.
AU - Kramer, John
AU - Bucholz, Kathleen K.
AU - Bierut, Laura J.
AU - Nurnberger, John
AU - Porjesz, Bernice
AU - Hesselbrock, Victor M.
N1 - Funding Information:
Research reported in this publication was supported by National Institute on AlcoholAbuse and Alcoholism (NIAAA) award numbers K01AA021145 (to Karen G. Chartier, principal investigator) and K02AA018755 (to Danielle M. Dick, principal investigator). This national collaborative study is supported byNational Institutes ofHealth (NIH)GrantU10AA008401 fromtheNIAAA and the National Institute on Drug Abuse (NIDA). The Genome Technology Access Center in the Department of Genetics at Washington University School of Medicine is partially supported by National Cancer Institute Cancer Center Support Grant #P30 CA91842 to the Siteman Cancer Center and by ICTS/CTSA Grant #UL1RR024992 from the National Center for Research Resources, a component of the NIH, and NIH Roadmap for Medical Research. Funding support for Genome-Wide Association Study genotyping, which was performed at The Johns Hopkins University Center for Inherited Disease Research, was provided by the NIAAA, the NIH GEI (U01HG004438), and the NIH contract ?High throughput genotyping for studying the genetic contributions to human disease? (HHSN268200782096C). This article was originally presented as a poster at theWorld Congress of Psychiatric Genetics
Publisher Copyright:
© 2016, Alcohol Research Documentation Inc. All rights reserved.
PY - 2016/5
Y1 - 2016/5
N2 - Objective: Variations in the genes encoding alcohol dehydrogenase (ADH) enzymes are associated with both alcohol consumption and dependence in multiple populations. Additionally, some environmental factors have been recognized as modifiers of these relationships. This study examined the modifying effect of religious involvement on relationships between ADH gene variants and alcohol consumption-related phenotypes. Method: Subjects were African American, European American, and Hispanic American adults with lifetime exposure to alcohol (N = 7,716; 53% female) from the Collaborative Study on the Genetics of Alcoholism. Genetic markers included ADH1B-rs1229984, ADH1B-rs2066702, ADH1C-rs698, ADH4-rs1042364, and ADH4-rs1800759. Phenotypes were maximum drinks consumed in a 24-hour period and total number of alcohol dependence symptoms according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Religious involvement was defined by self-reported religious services attendance. Results: Both religious involvement and ADH1B-rs1229984 were negatively associated with the number of maximum drinks consumed and the number of lifetime alcohol dependence symptoms endorsed. The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms. Risk variants had weaker associations with maximum drinks and alcohol dependence symptoms as a function of increasing religious involvement. Conclusions: This study provided initial evidence of a modifying effect for religious involvement on relationships between ADH variants and maximum drinks and alcohol dependence symptoms.
AB - Objective: Variations in the genes encoding alcohol dehydrogenase (ADH) enzymes are associated with both alcohol consumption and dependence in multiple populations. Additionally, some environmental factors have been recognized as modifiers of these relationships. This study examined the modifying effect of religious involvement on relationships between ADH gene variants and alcohol consumption-related phenotypes. Method: Subjects were African American, European American, and Hispanic American adults with lifetime exposure to alcohol (N = 7,716; 53% female) from the Collaborative Study on the Genetics of Alcoholism. Genetic markers included ADH1B-rs1229984, ADH1B-rs2066702, ADH1C-rs698, ADH4-rs1042364, and ADH4-rs1800759. Phenotypes were maximum drinks consumed in a 24-hour period and total number of alcohol dependence symptoms according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Religious involvement was defined by self-reported religious services attendance. Results: Both religious involvement and ADH1B-rs1229984 were negatively associated with the number of maximum drinks consumed and the number of lifetime alcohol dependence symptoms endorsed. The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms. Risk variants had weaker associations with maximum drinks and alcohol dependence symptoms as a function of increasing religious involvement. Conclusions: This study provided initial evidence of a modifying effect for religious involvement on relationships between ADH variants and maximum drinks and alcohol dependence symptoms.
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U2 - 10.15288/jsad.2016.77.393
DO - 10.15288/jsad.2016.77.393
M3 - Article
C2 - 27172571
AN - SCOPUS:84969134871
VL - 77
SP - 393
EP - 404
JO - Journal of Studies on Alcohol and Drugs
JF - Journal of Studies on Alcohol and Drugs
SN - 1937-1888
IS - 3
ER -