Interaction of Yersinia with the Gut: Mechanisms of pathogenesis and immune evasion

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Scopus citations

Abstract

Yersinia entercolitica and Yersinia pseudotuberculosis are human foodborne pathogens that interact extensively with tissues of the gut and the host's immune system to cause disease. As part of their pathogenic strategies, the Yersinia have evolved numerous ways to invade host tissues, gain essential nutrients, and evade host immunity. Technological advances over the last 10 years have revolutionized our understanding of host-pathogen interactions. The application of these new technologies has also shown that even well-understood pathogens such as the Yersinia have many surprises waiting to be revealed. The complex interaction with the host has made Yersinia a paradigm for understanding bacterial pathogenesis and the host response to invasive bacterial infections. This review examines the mechanisms of immune evasion employed by the Yersinia and highlights recent advances in understanding the host-pathogen interaction.

Original languageEnglish (US)
Title of host publicationMolecular Mechanisms of Bacterial Infection via the Gut
EditorsChihiro Sasakawa
Pages61-91
Number of pages31
Edition1
DOIs
StatePublished - Dec 1 2009

Publication series

NameCurrent Topics in Microbiology and Immunology
Number1
Volume337
ISSN (Print)0070-217X

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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