Interaction of ageing, photoperiod and melatonin on plasma thyroid hormones and cholesterol levels in female Syrian hamsters (Mesocricetus auratus)

M. K. Vaughan, B. A. Richardson, C. M. Craft, M. C. Powanda, Russel J Reiter

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13 Citations (Scopus)

Abstract

Plasma levels of thyroxine (T 4), triiodothyronine (T 3) and growth hormone (GH) as well as the free T 4 and free T 3 index (FT 4I, FT 3I) in 20-month-old female Syrian hamsters kept under long daily photoperiod [light:dark (LD) cycles of 14:10] were significantly depressed compared to the values of 2-month-old animals kept under the same photoperiodic conditions. Cholesterol levels in old females were significantly elevated compared to those in young animals. In a subsequent experiment, young (4 month) and old (15 month) female hamsters were either placed in a short photoperiod (10:14 LD) or a 14:10 LD cycle and given daily afternoon injection of either diluent or 25 μg melatonin. After 8 weeks, the old females, regardless of treatment or photoperiod, had significantly lower T 4 levels and higher cholesterol and triglyceride levels than did young animals. In 14:10 LD, FT 4I and FT 3I did not differ between young and old animals, possibly because of the reduced age gap in this experiment. Although the FT 4I and FT 3I in young females after 8 weeks of treatment with 10:14 LD or melatonin were not significant, the old females did demonstrate a significant suppression of their FT 4I and FT 3I values.

Original languageEnglish (US)
Pages (from-to)345-353
Number of pages9
JournalGerontology
Volume28
Issue number6
StatePublished - 1982

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Mesocricetus
Photoperiod
Melatonin
Thyroid Hormones
Cholesterol
Light
Triiodothyronine
Hypercholesterolemia
Thyroxine
Cricetinae
Growth Hormone
Triglycerides
Injections
Therapeutics

ASJC Scopus subject areas

  • Aging

Cite this

Interaction of ageing, photoperiod and melatonin on plasma thyroid hormones and cholesterol levels in female Syrian hamsters (Mesocricetus auratus). / Vaughan, M. K.; Richardson, B. A.; Craft, C. M.; Powanda, M. C.; Reiter, Russel J.

In: Gerontology, Vol. 28, No. 6, 1982, p. 345-353.

Research output: Contribution to journalArticle

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