Interaction between Common Genetic Variants and Total Fat Intake on Low-Density Lipoprotein Peak Particle Diameter: A Genome-Wide Association Study

Iwona Rudkowska, Louis Pérusse, Claire Bellis, John Blangero, Jean Pierre Després, Claude Bouchard, Marie Claude Vohl

    Research output: Contribution to journalArticle

    8 Scopus citations

    Abstract

    Background/Aim: Total fat intake has an important impact on the low-density lipoprotein (LDL) peak particle diameter (LDL-PPD) and may interact with nutrient-sensitive single nucleotide polymorphisms (SNPs). The objective was to examine whether there is suggestive evidence of SNP × dietary fat intake interaction effects influencing the LDL-PPD in the Quebec Family Study (QFS) in order to generate hypotheses to be tested in larger studies. Methods: SNPs from a genome-wide association study (GWAS) using Illumina Human610-Quad BeadChip, total fat intake derived from a 3-day weighted food record, and SNP × total fat intake interaction effects were examined on LDL-PPD in 541 QFS subjects. Results: The GWAS analyses 29 identified independent SNP × total fat intake interaction effects on the LDL-PPD at p < 10<sup>-5</sup>, including SNPs in the following genes: ABCG2, CPA3, FNBP1, KCNQ3, NBAS, NCALD, OPRL1, NKAIN2, SH3BGRL2, SOX5, and SUSD4. Conclusions: This observational study suggests that multiple SNPs interact with dietary fat intake to influence variation in the LDL-PPD.

    Original languageEnglish (US)
    Pages (from-to)44-53
    Number of pages10
    JournalJournal of Nutrigenetics and Nutrigenomics
    DOIs
    StateAccepted/In press - Jun 20 2015

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Genetics
    • Food Science

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