TY - JOUR
T1 - Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes
T2 - A polygenic approach to obesity
AU - Sáez, María E.
AU - Grilo, Antonio
AU - Morón, Francisco J.
AU - Manzano, Luis
AU - Martínez-Larrad, María T.
AU - González-Pérez, Antonio
AU - Serrano-Hernando, Javier
AU - Ruiz, Agustín
AU - Ramírez-Lorca, Reposo
AU - Serrano-Ríos, Manuel
PY - 2008/7/25
Y1 - 2008/7/25
N2 - Context: Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed. Objective: To investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of the peroxisome proliferator-activated receptors family. Design: Cross-sectional, genetic association study and gene-gene interaction analysis. Subjects: The study sample comprise 1953 individuals, 725 obese (defined as body mass index ≥ 30) and 1228 non obese subjects. Results: In the monogenic analysis, only the peroxisome proliferator-activated receptor delta (PPARD) gene was associated with obesity (OR = 1.43 [1.04-1.97], p = 0.027). In addition, we have found a significant interaction between CAPN5 and PPARD genes (p = 0.038) that reduces the risk for obesity in a 55%. Conclusion: Our results suggest that CAPN5 and PPARD gene products may also interact in vivo.
AB - Context: Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed. Objective: To investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of the peroxisome proliferator-activated receptors family. Design: Cross-sectional, genetic association study and gene-gene interaction analysis. Subjects: The study sample comprise 1953 individuals, 725 obese (defined as body mass index ≥ 30) and 1228 non obese subjects. Results: In the monogenic analysis, only the peroxisome proliferator-activated receptor delta (PPARD) gene was associated with obesity (OR = 1.43 [1.04-1.97], p = 0.027). In addition, we have found a significant interaction between CAPN5 and PPARD genes (p = 0.038) that reduces the risk for obesity in a 55%. Conclusion: Our results suggest that CAPN5 and PPARD gene products may also interact in vivo.
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U2 - 10.1186/1475-2840-7-23
DO - 10.1186/1475-2840-7-23
M3 - Article
C2 - 18657264
AN - SCOPUS:51249089430
SN - 1475-2840
VL - 7
JO - Cardiovascular Diabetology
JF - Cardiovascular Diabetology
M1 - 23
ER -