TY - JOUR
T1 - Interaction between 1,4-butanediol and ethanol on operant responding and the cardiovascular system
AU - Gerak, Lisa R.
AU - Hicks, Alissa R.
AU - Winsauer, Peter J.
AU - Varner, Kurt J.
PY - 2004/12/3
Y1 - 2004/12/3
N2 - The current studies characterized the rate-decreasing and cardiovascular responses produced by 1,4-butanediol administered alone and in combination with ethanol to test the hypothesis that these effects resulted from the degradation of 1,4-butanediol to γ-hydroxybutyrate. One group of rats responded under a fixed-ratio 20 schedule of food presentation; ethanol and 1,4-butanediol dose-dependently decreased response rates. Ethanol administered in combination with 1,4-butanediol attenuated the rate-decreasing effects of 1,4-butanediol without altering the potency of ethanol. In separate groups of conscious rats, radio telemetry was used to record mean arterial pressure and heart rate. In contrast to its depressant effects on schedule-controlled responding, 1,4-butanediol increased mean arterial pressure and heart rate; these increases were attenuated by ethanol. Thus, the behavioral and cardiovascular actions of 1,4-butanediol are similar to those elicited by γ-hydroxybutyrate. The ability of ethanol to attenuate the behavioral and cardiovascular effects of 1,4-butanediol indicates that these effects require the conversion of 1,4-butanediol to γ-hydroxybutyrate.
AB - The current studies characterized the rate-decreasing and cardiovascular responses produced by 1,4-butanediol administered alone and in combination with ethanol to test the hypothesis that these effects resulted from the degradation of 1,4-butanediol to γ-hydroxybutyrate. One group of rats responded under a fixed-ratio 20 schedule of food presentation; ethanol and 1,4-butanediol dose-dependently decreased response rates. Ethanol administered in combination with 1,4-butanediol attenuated the rate-decreasing effects of 1,4-butanediol without altering the potency of ethanol. In separate groups of conscious rats, radio telemetry was used to record mean arterial pressure and heart rate. In contrast to its depressant effects on schedule-controlled responding, 1,4-butanediol increased mean arterial pressure and heart rate; these increases were attenuated by ethanol. Thus, the behavioral and cardiovascular actions of 1,4-butanediol are similar to those elicited by γ-hydroxybutyrate. The ability of ethanol to attenuate the behavioral and cardiovascular effects of 1,4-butanediol indicates that these effects require the conversion of 1,4-butanediol to γ-hydroxybutyrate.
KW - 1,4-Butanediol
KW - Heart rate
KW - Mean arterial pressure
KW - Radio telemetry
KW - Rat
KW - Schedule-controlled behavior
UR - http://www.scopus.com/inward/record.url?scp=9644282923&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9644282923&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2004.10.044
DO - 10.1016/j.ejphar.2004.10.044
M3 - Article
C2 - 15588627
AN - SCOPUS:9644282923
VL - 506
SP - 75
EP - 82
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -