Integrin-linked kinase 1: Role in hormonal cancer progression

Valerie Cortez, Binoj C. Nair, Dimple Chakravarty, Ratna K Vadlamudi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Integrin-linked kinase 1 (ILK1) is a serine/threonine kinase that plays important roles in a variety of cellular functions including cell survival, migration and angiogenesis. ILK1 is normally expressed in numerous tissues and activated by growth factors, cytokines and hormones. Dysregulation of ILK1 expression or function is found in several hormonal tumors including breast, ovary and prostate. Emerging evidence suggests that ILK overexpression promotes cellular transformation, cell survival, epithelial mesenchymal transition (EMT), and metastasis of hormonal cancer cells while inhibition of ILK1 reduces tumor growth and progression. The recent development of ILK1 inhibitors has provided novel mechanisms for blocking ILK1 signaling to curb metastasis and therapy resistance of hormonal tumors. This review will focus on recent advances made towards understanding the role of ILK signaling axis in progression of hormonal cancer.

Original languageEnglish (US)
Pages (from-to)788-796
Number of pages9
JournalFrontiers in Bioscience - Scholar
Volume3 S
Issue number2
StatePublished - Jan 1 2011

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Tumors
Neoplasms
Cell Survival
Cells
Neoplasm Metastasis
Curbs
Epithelial-Mesenchymal Transition
Protein-Serine-Threonine Kinases
Growth Hormone
Cell Movement
integrin-linked kinase
Prostate
Ovary
Intercellular Signaling Peptides and Proteins
Hormones
Tissue
Breast Neoplasms
Cytokines
Growth
Therapeutics

Keywords

  • AKT
  • EMT
  • ErbB2
  • Estrogen receptor
  • Hormonal signaling
  • Integrin linked kinase
  • Metastasis
  • Therapy resistance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Integrin-linked kinase 1 : Role in hormonal cancer progression. / Cortez, Valerie; Nair, Binoj C.; Chakravarty, Dimple; Vadlamudi, Ratna K.

In: Frontiers in Bioscience - Scholar, Vol. 3 S, No. 2, 01.01.2011, p. 788-796.

Research output: Contribution to journalArticle

Cortez, V, Nair, BC, Chakravarty, D & Vadlamudi, RK 2011, 'Integrin-linked kinase 1: Role in hormonal cancer progression', Frontiers in Bioscience - Scholar, vol. 3 S, no. 2, pp. 788-796.
Cortez, Valerie ; Nair, Binoj C. ; Chakravarty, Dimple ; Vadlamudi, Ratna K. / Integrin-linked kinase 1 : Role in hormonal cancer progression. In: Frontiers in Bioscience - Scholar. 2011 ; Vol. 3 S, No. 2. pp. 788-796.
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