TY - JOUR
T1 - Integrative cognitive remediation for early psychosis
T2 - Results from a randomized controlled trial
AU - Vidarsdottir, Olina G.
AU - Roberts, David L.
AU - Twamley, Elizabeth W.
AU - Gudmundsdottir, Berglind
AU - Sigurdsson, Engilbert
AU - Magnusdottir, Brynja B.
N1 - Funding Information:
This work was supported by Landspitali-The National University Hospital of Iceland 2016/2017, The University of Iceland 2017/2018 and Arnór Björnsson Memorial Fund 2015.
PY - 2019/3
Y1 - 2019/3
N2 - Early application of cognitive remediation may help prevent the development of long-term functional impairments that characterize psychotic disorders. Interventions that encompass both neurocognitive and social-cognitive training may work synergistically to bridge the gap between cognitive gains and functional outcomes in early psychosis. We integrated three cognitive remediation approaches: Neuropsychological Educational Approach to Remediation (NEAR), Compensatory Cognitive Training (CCT), and Social Cognition and Interaction Training (SCIT), and evaluated the effects on cognition, clinical symptoms, self-assessed and informant-assessed social functioning in early psychosis. A total of 49 patients diagnosed with primary psychotic disorder seeking service at an early-intervention service in Iceland were randomized to either a waiting-list control group (n = 24) or a 12-week group-based integrative cognitive remediation (n = 25). Neurocognition, social cognition, community functioning and clinical symptoms were assessed at baseline and post-treatment. The intervention group showed significant improvements in verbal memory, cognitive flexibility, working memory, ToM and a significant reduction in hostile attributions, compared to those receiving standard treatment alone, but there were no differences between groups on measures of social functioning or clinical symptoms. The intervention was well tolerated and received high treatment satisfaction ratings. Findings indicate that integrated cognitive remediation has potential to improve neurocognition and social cognition in early psychosis.
AB - Early application of cognitive remediation may help prevent the development of long-term functional impairments that characterize psychotic disorders. Interventions that encompass both neurocognitive and social-cognitive training may work synergistically to bridge the gap between cognitive gains and functional outcomes in early psychosis. We integrated three cognitive remediation approaches: Neuropsychological Educational Approach to Remediation (NEAR), Compensatory Cognitive Training (CCT), and Social Cognition and Interaction Training (SCIT), and evaluated the effects on cognition, clinical symptoms, self-assessed and informant-assessed social functioning in early psychosis. A total of 49 patients diagnosed with primary psychotic disorder seeking service at an early-intervention service in Iceland were randomized to either a waiting-list control group (n = 24) or a 12-week group-based integrative cognitive remediation (n = 25). Neurocognition, social cognition, community functioning and clinical symptoms were assessed at baseline and post-treatment. The intervention group showed significant improvements in verbal memory, cognitive flexibility, working memory, ToM and a significant reduction in hostile attributions, compared to those receiving standard treatment alone, but there were no differences between groups on measures of social functioning or clinical symptoms. The intervention was well tolerated and received high treatment satisfaction ratings. Findings indicate that integrated cognitive remediation has potential to improve neurocognition and social cognition in early psychosis.
KW - Compensatory Cognitive Training
KW - Functional outcome
KW - Neurocognition
KW - Schizophrenia
KW - Social Cognition and Interaction Training
KW - Theory of mind
KW - Verbal memory
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U2 - 10.1016/j.psychres.2019.02.007
DO - 10.1016/j.psychres.2019.02.007
M3 - Article
C2 - 31207854
AN - SCOPUS:85061056820
VL - 273
SP - 690
EP - 698
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
ER -