Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.

Frank Desiere, Eric W. Deutsch, Alexey I. Nesvizhskii, Parag Mallick, Nichole L. King, Jimmy K. Eng, Alan Aderem, Rose Boyle, Erich Brunner, Samuel Donohoe, Nelson Fausto, Ernst Hafen, Lee Hood, Michael G. Katze, Kathleen A. Kennedy, Floyd Kregenow, Hookeun Lee, Biaoyang Lin, Dan Martin, Jeffrey A. RanishDavid J. Rawlings, Lawrence E. Samelson, Yuzuru Shiio, Julian D. Watts, Bernd Wollscheid, Michael E. Wright, Wei Yan, Lihong Yang, Eugene C. Yi, Hui Zhang, Ruedi Aebersold

Research output: Contribution to journalArticlepeer-review

232 Scopus citations

Abstract

A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping of peptides derived from accurate interpretations of protein tandem mass spectrometry (MS) data to eukaryotic genomes and the generation of an expandable resource for integration of data from many diverse proteomics experiments. Furthermore, we demonstrate that peptide identifications obtained from high-throughput proteomics can be integrated on a large scale with the human genome. This resource could serve as an expandable repository for MS-derived proteome information.

Original languageEnglish (US)
Pages (from-to)R9
JournalGenome biology
Volume6
Issue number1
StatePublished - 2005

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

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