Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.

Frank Desiere; Eric W. Deutsch; Alexey I. Nesvizhskii; Parag Mallick; Nichole L. King; Jimmy K. Eng; Alan Aderem; Rose Boyle; Erich Brunner; Samuel Donohoe; Nelson Fausto; Ernst Hafen; Lee Hood; Michael G. Katze; Kathleen A. Kennedy; Floyd Kregenow; Hookeun Lee; Biaoyang Lin; Dan Martin; Jeffrey A. Ranish; David J. Rawlings; Lawrence E. Samelson; Yuzuru Shiio; Julian D. Watts; Bernd Wollscheid; Michael E. Wright; Wei Yan; Lihong Yang; Eugene C. Yi; Hui Zhang; Ruedi Aebersold

Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.

Frank Desiere, Eric W. Deutsch, Alexey I. Nesvizhskii, Parag Mallick, Nichole L. King, Jimmy K. Eng, Alan Aderem, Rose Boyle, Erich Brunner, Samuel Donohoe, Nelson Fausto, Ernst Hafen, Lee Hood, Michael G. Katze, Kathleen A. Kennedy, Floyd Kregenow, Hookeun Lee, Biaoyang Lin, Dan Martin, Jeffrey A. RanishDavid J. Rawlings, Lawrence E. Samelson, Yuzuru Shiio, Julian D. Watts, Bernd Wollscheid, Michael E. Wright, Wei Yan, Lihong Yang, Eugene C. Yi, Hui Zhang, Ruedi Aebersold

Greehey Children's Cancer Research Institute

Research output: Contribution to journal › Article › peer-review

269 Scopus citations

Abstract

A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping of peptides derived from accurate interpretations of protein tandem mass spectrometry (MS) data to eukaryotic genomes and the generation of an expandable resource for integration of data from many diverse proteomics experiments. Furthermore, we demonstrate that peptide identifications obtained from high-throughput proteomics can be integrated on a large scale with the human genome. This resource could serve as an expandable repository for MS-derived proteome information.

Original language	English (US)
Pages (from-to)	R9
Journal	Genome biology
Volume	6
Issue number	1
State	Published - 2005

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics
Cell Biology

Cite this

Desiere, F., Deutsch, E. W., Nesvizhskii, A. I., Mallick, P., King, N. L., Eng, J. K., Aderem, A., Boyle, R., Brunner, E., Donohoe, S., Fausto, N., Hafen, E., Hood, L., Katze, M. G., Kennedy, K. A., Kregenow, F., Lee, H., Lin, B., Martin, D., ... Aebersold, R. (2005). Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome biology, 6(1), R9.

Desiere, F, Deutsch, EW, Nesvizhskii, AI, Mallick, P, King, NL, Eng, JK, Aderem, A, Boyle, R, Brunner, E, Donohoe, S, Fausto, N, Hafen, E, Hood, L, Katze, MG, Kennedy, KA, Kregenow, F, Lee, H, Lin, B, Martin, D, Ranish, JA, Rawlings, DJ, Samelson, LE, Shiio, Y, Watts, JD, Wollscheid, B, Wright, ME, Yan, W, Yang, L, Yi, EC, Zhang, H & Aebersold, R 2005, 'Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.', Genome biology, vol. 6, no. 1, pp. R9.

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abstract = "A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping of peptides derived from accurate interpretations of protein tandem mass spectrometry (MS) data to eukaryotic genomes and the generation of an expandable resource for integration of data from many diverse proteomics experiments. Furthermore, we demonstrate that peptide identifications obtained from high-throughput proteomics can be integrated on a large scale with the human genome. This resource could serve as an expandable repository for MS-derived proteome information.",

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AU - King, Nichole L.

AU - Eng, Jimmy K.

AU - Aderem, Alan

AU - Boyle, Rose

AU - Brunner, Erich

AU - Donohoe, Samuel

AU - Fausto, Nelson

AU - Hafen, Ernst

AU - Hood, Lee

AU - Katze, Michael G.

AU - Kennedy, Kathleen A.

AU - Kregenow, Floyd

AU - Lee, Hookeun

AU - Lin, Biaoyang

AU - Martin, Dan

AU - Ranish, Jeffrey A.

AU - Rawlings, David J.

AU - Samelson, Lawrence E.

AU - Shiio, Yuzuru

AU - Watts, Julian D.

AU - Wollscheid, Bernd

AU - Wright, Michael E.

AU - Yan, Wei

AU - Yang, Lihong

AU - Yi, Eugene C.

AU - Zhang, Hui

AU - Aebersold, Ruedi

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Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.

Abstract

ASJC Scopus subject areas

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