Intact natural killer activity in chronic granulomatous disease: Evidence against an oxygen-dependent cytotoxic mechanism

A. El Hag; R. A. Clark

Intact natural killer activity in chronic granulomatous disease: Evidence against an oxygen-dependent cytotoxic mechanism

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Abstract

NK activity was evaluated in three patients with chronic granulomatous disease (CGD), a disorder in which phagocytic cells fail to undergo a stimulus-dependent burst of oxidative metabolism and thus do not generate toxic oxygen derivatives. In spite of the inability to produce reactive oxygen species, CGD mononuclear cells have normal NK activity.

Original language	English (US)
Pages (from-to)	569-570
Number of pages	2
Journal	Journal of Immunology
Volume	132
Issue number	2
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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title = "Intact natural killer activity in chronic granulomatous disease: Evidence against an oxygen-dependent cytotoxic mechanism",

abstract = "NK activity was evaluated in three patients with chronic granulomatous disease (CGD), a disorder in which phagocytic cells fail to undergo a stimulus-dependent burst of oxidative metabolism and thus do not generate toxic oxygen derivatives. In spite of the inability to produce reactive oxygen species, CGD mononuclear cells have normal NK activity.",

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year = "1984",

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AU - El Hag, A.

AU - Clark, R. A.

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AB - NK activity was evaluated in three patients with chronic granulomatous disease (CGD), a disorder in which phagocytic cells fail to undergo a stimulus-dependent burst of oxidative metabolism and thus do not generate toxic oxygen derivatives. In spite of the inability to produce reactive oxygen species, CGD mononuclear cells have normal NK activity.

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Intact natural killer activity in chronic granulomatous disease: Evidence against an oxygen-dependent cytotoxic mechanism

Abstract

ASJC Scopus subject areas

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