Intact natural killer activity in chronic granulomatous disease: Evidence against an oxygen-dependent cytotoxic mechanism

A. El Hag, R. A. Clark

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

NK activity was evaluated in three patients with chronic granulomatous disease (CGD), a disorder in which phagocytic cells fail to undergo a stimulus-dependent burst of oxidative metabolism and thus do not generate toxic oxygen derivatives. In spite of the inability to produce reactive oxygen species, CGD mononuclear cells have normal NK activity.

Original languageEnglish (US)
Pages (from-to)569-570
Number of pages2
JournalJournal of Immunology
Volume132
Issue number2
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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