Intact natural killer activity in chronic granulomatous disease

Evidence against an oxygen-dependent cytotoxic mechanism

A. El Hag, Robert A Clark

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

NK activity was evaluated in three patients with chronic granulomatous disease (CGD), a disorder in which phagocytic cells fail to undergo a stimulus-dependent burst of oxidative metabolism and thus do not generate toxic oxygen derivatives. In spite of the inability to produce reactive oxygen species, CGD mononuclear cells have normal NK activity.

Original languageEnglish (US)
Pages (from-to)569-570
Number of pages2
JournalJournal of Immunology
Volume132
Issue number2
StatePublished - 1984
Externally publishedYes

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Chronic Granulomatous Disease
Oxygen
Respiratory Burst
Poisons
Phagocytes
Reactive Oxygen Species

ASJC Scopus subject areas

  • Immunology

Cite this

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abstract = "NK activity was evaluated in three patients with chronic granulomatous disease (CGD), a disorder in which phagocytic cells fail to undergo a stimulus-dependent burst of oxidative metabolism and thus do not generate toxic oxygen derivatives. In spite of the inability to produce reactive oxygen species, CGD mononuclear cells have normal NK activity.",
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