Insulin sensitivity and Lp(a) concentrations in normoglycemic men

Steven M. Haffner, Pauli Karhapaa, David L. Rainwater, Leena Mykkanen, Gilbert Aldrete, Markku Laakso

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


OBJECTIVE - Increased lipoprotein(a) [Lp(a)] concentrations have been recognized as a risk factor for coronary heart disease. Little data exists on the relationship of Lp(a) concentrations to insulin resistance. RESEARCH DESIGN AND METHODS - We examined insulin resistance (as determined by the euglycemic clamp) together with indirect calorimetry in relation to Lp(a) concentrations, apolipoprotein(a) [apo(a)] molecular weight, and apo(a) phenotype in 87 normoglycemic men. RESULTS - Lp(a) concentrations were significantly related to total (r = 0.225) and nonoxidative (r = 0.256) whole-body glucose disposal. These results suggest a positive but weak association between insulin sensitivity (restricted to the nonoxidative whole-body glucose disposal) and Lp(a) concentrations. However, after adjustment for apo(a) molecular weight [which accounts for some of the genetic influences on Lp(a) levels], total and nonoxidative body glucose disposal were not significantly related to Lp(a) concentrations. CONCLUSIONS - Normoglycemic insulin-resistant subjects do not have elevated Lp(a) concentrations.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalDiabetes care
Issue number2
StatePublished - Feb 1995
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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