Insulin secretion, insulin resistance, and obesity

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Insulin resistance and hyperinsulinemia are present in the majority of obese subjects if they are over 50% of ideal body weight. The insulin resistance is manifested by decreased uptake of glucose by peripheral tissues (muscle) and impaired suppression of hepatic glucose production. Both of these abnormalities can be improved by physical training.

Original languageEnglish (US)
Pages (from-to)73-82
Number of pages10
JournalInternational Journal of Obesity
Volume6
Issue numberSuppl. 1
StatePublished - 1982
Externally publishedYes

Fingerprint

insulin secretion
insulin resistance
Insulin Resistance
obesity
Obesity
Insulin
ideal body weight
Glucose
Ideal Body Weight
glucose
hyperinsulinemia
Hyperinsulinism
muscle tissues
uptake mechanisms
Muscles
liver
Liver

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

Cite this

Insulin secretion, insulin resistance, and obesity. / Defronzo, Ralph A.

In: International Journal of Obesity, Vol. 6, No. Suppl. 1, 1982, p. 73-82.

Research output: Contribution to journalArticle

@article{81d5a5f46d524a448013872d21e3d095,
title = "Insulin secretion, insulin resistance, and obesity",
abstract = "Insulin resistance and hyperinsulinemia are present in the majority of obese subjects if they are over 50{\%} of ideal body weight. The insulin resistance is manifested by decreased uptake of glucose by peripheral tissues (muscle) and impaired suppression of hepatic glucose production. Both of these abnormalities can be improved by physical training.",
author = "Defronzo, {Ralph A}",
year = "1982",
language = "English (US)",
volume = "6",
pages = "73--82",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "Suppl. 1",

}

TY - JOUR

T1 - Insulin secretion, insulin resistance, and obesity

AU - Defronzo, Ralph A

PY - 1982

Y1 - 1982

N2 - Insulin resistance and hyperinsulinemia are present in the majority of obese subjects if they are over 50% of ideal body weight. The insulin resistance is manifested by decreased uptake of glucose by peripheral tissues (muscle) and impaired suppression of hepatic glucose production. Both of these abnormalities can be improved by physical training.

AB - Insulin resistance and hyperinsulinemia are present in the majority of obese subjects if they are over 50% of ideal body weight. The insulin resistance is manifested by decreased uptake of glucose by peripheral tissues (muscle) and impaired suppression of hepatic glucose production. Both of these abnormalities can be improved by physical training.

UR - http://www.scopus.com/inward/record.url?scp=0020319478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020319478&partnerID=8YFLogxK

M3 - Article

C2 - 6749725

AN - SCOPUS:0020319478

VL - 6

SP - 73

EP - 82

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - Suppl. 1

ER -