Insulin resistance the link between t2dm and cvd: Basic mechanisms and clinical implications

Muhammad A. Abdul-Ghani; Amin Jayyousi; Ralph A. Defronzo; Nidal Asaad; Jassim Al-Suwaidi

doi:10.2174/1570161115666171010115119

Insulin resistance the link between t2dm and cvd: Basic mechanisms and clinical implications

Muhammad A. Abdul-Ghani, Amin Jayyousi, Ralph A. Defronzo, Nidal Asaad, Jassim Al-Suwaidi

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Insulin Resistance (IR) is a cardinal feature of Type 2 Diabetes Mellitus (T2DM). It also is associated with multiple metabolic abnormalities which are known Cardiovascular Disease (CVD) risk factors. Thus, IR not only contributes to the development of hyperglycemia in T2DM patients, but also to the elevated CVD risk. Improving insulin sensitivity is anticipated to both lower the plasma glucose concentration and decrease CVD risk in T2DM patients, independent of glucose control. We review the molecular mechanisms and metabolic consequences of IR in T2DM patients and discuss the importance of addressing IR in the management of T2DM.

Original language	English (US)
Pages (from-to)	153-163
Number of pages	11
Journal	Current Vascular Pharmacology
Volume	17
Issue number	2
DOIs	https://doi.org/10.2174/1570161115666171010115119
State	Published - 2018

Keywords

Cardiovascular disease
HDL
Insulin resistance
Insulin sensitizers
LDL
Type 2 diabetes

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine

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10.2174/1570161115666171010115119

Cite this

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title = "Insulin resistance the link between t2dm and cvd: Basic mechanisms and clinical implications",

abstract = "Insulin Resistance (IR) is a cardinal feature of Type 2 Diabetes Mellitus (T2DM). It also is associated with multiple metabolic abnormalities which are known Cardiovascular Disease (CVD) risk factors. Thus, IR not only contributes to the development of hyperglycemia in T2DM patients, but also to the elevated CVD risk. Improving insulin sensitivity is anticipated to both lower the plasma glucose concentration and decrease CVD risk in T2DM patients, independent of glucose control. We review the molecular mechanisms and metabolic consequences of IR in T2DM patients and discuss the importance of addressing IR in the management of T2DM.",

keywords = "Cardiovascular disease, HDL, Insulin resistance, Insulin sensitizers, LDL, Type 2 diabetes",

author = "Abdul-Ghani, {Muhammad A.} and Amin Jayyousi and Defronzo, {Ralph A.} and Nidal Asaad and Jassim Al-Suwaidi",

note = "Funding Information: MAG is supported by grants fron Qatar Foundation, the NIH and the American Diabetes Ascoiation. RAD received Funding Information: grant support from the NIH and the American Diabetes Association. JA received grant support from Qatar Foundation. Publisher Copyright: {\textcopyright} 2019 Bentham Science Publishers.",

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doi = "10.2174/1570161115666171010115119",

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volume = "17",

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T1 - Insulin resistance the link between t2dm and cvd

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AU - Abdul-Ghani, Muhammad A.

AU - Jayyousi, Amin

AU - Defronzo, Ralph A.

AU - Asaad, Nidal

AU - Al-Suwaidi, Jassim

N1 - Funding Information: MAG is supported by grants fron Qatar Foundation, the NIH and the American Diabetes Ascoiation. RAD received Funding Information: grant support from the NIH and the American Diabetes Association. JA received grant support from Qatar Foundation. Publisher Copyright: © 2019 Bentham Science Publishers.

PY - 2018

Y1 - 2018

N2 - Insulin Resistance (IR) is a cardinal feature of Type 2 Diabetes Mellitus (T2DM). It also is associated with multiple metabolic abnormalities which are known Cardiovascular Disease (CVD) risk factors. Thus, IR not only contributes to the development of hyperglycemia in T2DM patients, but also to the elevated CVD risk. Improving insulin sensitivity is anticipated to both lower the plasma glucose concentration and decrease CVD risk in T2DM patients, independent of glucose control. We review the molecular mechanisms and metabolic consequences of IR in T2DM patients and discuss the importance of addressing IR in the management of T2DM.

AB - Insulin Resistance (IR) is a cardinal feature of Type 2 Diabetes Mellitus (T2DM). It also is associated with multiple metabolic abnormalities which are known Cardiovascular Disease (CVD) risk factors. Thus, IR not only contributes to the development of hyperglycemia in T2DM patients, but also to the elevated CVD risk. Improving insulin sensitivity is anticipated to both lower the plasma glucose concentration and decrease CVD risk in T2DM patients, independent of glucose control. We review the molecular mechanisms and metabolic consequences of IR in T2DM patients and discuss the importance of addressing IR in the management of T2DM.

KW - Cardiovascular disease

KW - HDL

KW - Insulin resistance

KW - Insulin sensitizers

KW - LDL

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Insulin resistance the link between t2dm and cvd: Basic mechanisms and clinical implications

Abstract

Keywords

ASJC Scopus subject areas

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