Insulin resistance the link between t2dm and cvd: Basic mechanisms and clinical implications

Muhammad A. Abdul-Ghani, Amin Jayyousi, Ralph A. Defronzo, Nidal Asaad, Jassim Al-Suwaidi

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Insulin Resistance (IR) is a cardinal feature of Type 2 Diabetes Mellitus (T2DM). It also is associated with multiple metabolic abnormalities which are known Cardiovascular Disease (CVD) risk factors. Thus, IR not only contributes to the development of hyperglycemia in T2DM patients, but also to the elevated CVD risk. Improving insulin sensitivity is anticipated to both lower the plasma glucose concentration and decrease CVD risk in T2DM patients, independent of glucose control. We review the molecular mechanisms and metabolic consequences of IR in T2DM patients and discuss the importance of addressing IR in the management of T2DM.

Original languageEnglish (US)
Pages (from-to)153-163
Number of pages11
JournalCurrent Vascular Pharmacology
Volume17
Issue number2
DOIs
StatePublished - Jan 1 2018

Keywords

  • Cardiovascular disease
  • HDL
  • Insulin resistance
  • Insulin sensitizers
  • LDL
  • Type 2 diabetes

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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