Insulin resistance and atrial fibrillation (from the Framingham Heart Study)

Joo D. Fontes, Asya Lyass, Joseph M. Massaro, Michiel Rienstra, Dhayana Dallmeier, Renate B. Schnabel, Thomas J. Wang, Ramachandran S. Vasan, Steven A. Lubitz, Jared W. Magnani, Daniel Levy, Patrick T. Ellinor, Caroline S. Fox, Emelia J. Benjamin

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Diabetes mellitus and obesity are increasing in prevalence and are associated with an elevated risk of atrial fibrillation (AF). Given the aging of the United States population, AF is projected to concomitantly increase in prevalence in the upcoming decades. Both diabetes and obesity are associated with insulin resistance. Whether insulin resistance is an intermediate step for the development of AF is uncertain. We hypothesized that insulin resistance is associated with an increased risk of incident AF. We examined the association of insulin resistance with incident AF using multivariate Cox proportional hazards regression analysis adjusting for the established AF risk factors (i.e., age, gender, systolic blood pressure, hypertension treatment, PR interval, significant heart murmur, heart failure, and body mass index). Of the 3,023 eligible participants (55% women; mean age 59 years) representing 4,583 person-examinations (Framingham Offspring fifth and seventh examination cycles), 279 participants developed AF (9.3%) within ≤10 years of follow-up. With multivariate modeling, insulin resistance was not significantly associated with incident AF (hazard ratio comparing top quartile to other 3 quartiles of homeostatic model assessment index 1.18, 95% confidence interval 0.84 to 1.65, p = 0.34). In a community-based cohort with ≤10 years of follow-up, no significant association was observed between insulin resistance and incident AF.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalAmerican Journal of Cardiology
Issue number1
StatePublished - Jan 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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