Insulin resistance: A universal finding in diabetic states

R. A. Defronzo, D. Simonson, E. Ferrannini, E. Barrett

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We review the pathogenesis of the most common diabetic conditions: 1) non-insulin-dependent (Type ii, maturity-onset) diabetes mellitus; 2) insulin-dependent (Type I, juvenile-onset) diabetes mellitus; and 3) diabetic ketoacidosis. Particular emphasis will be placed on the contribution of insulin resistance to the glucose intolerance observed in these three states. Both the site and mechanism(s) of the glucose intolerance will be discussed.

Original languageEnglish (US)
Pages (from-to)223-238
Number of pages16
JournalBulletin der Schweizerischen Akademie der Medizinischen Wissenschaften
Issue numberMeet.
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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