Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis

R. A. DeFronzo

Research output: Contribution to journalArticle

198 Scopus citations


Insulin resistance syndrome (IRS) has the potential to explain a large group of common metabolic and cardiovascular disorders [e.g., obesity, non- insulin-dependent diabetes mellitus (NIDDM), hypertension, hyperlipidaemia, hypercoagulability] which are all in themselves cardiovascular risk factors. This contribution firstly reviews the convincing evidence from glucose-clamp studies that all of these conditions are characterised by the presence of combined insulin resistance and hyperinsulinaemia, and secondly examines the relationships of the components of this syndrome to coronary artery disease and to the rational choice of antihypertensive therapy.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalNetherlands Journal of Medicine
Issue number5
StatePublished - May 1 1997



  • Antihypertensive therapy
  • Dyslipidaemia
  • Glucose clamp
  • Hypertension
  • Insulin resistance syndrome
  • Obesity

ASJC Scopus subject areas

  • Internal Medicine

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